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Titolo:
Application of Carbopol (R) to controlled release preparations I. Carbopol(R) as a novel coating material
Autore:
Muramatsu, M; Kanada, K; Nishida, A; Ouchi, K; Saito, N; Yoshida, M; Shimoaka, A; Ozeki, T; Yuasa, H; Kanaya, Y;
Indirizzi:
Kissei Pharmaceut Co Ltd, Pharmaceut Labs, Nagano 3998304, Japan Kissei Pharmaceut Co Ltd Nagano Japan 3998304 abs, Nagano 3998304, Japan CBC Co Ltd, Chuo Ku, Tokyo 1040052, Japan CBC Co Ltd Tokyo Japan 1040052CBC Co Ltd, Chuo Ku, Tokyo 1040052, Japan Tokyo Univ Pharm & Life Sci, Sch Pharm, Lab Med & Pharmaceut Technol, Tokyo 1920392, Japan Tokyo Univ Pharm & Life Sci Tokyo Japan 1920392 ol, Tokyo 1920392, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 1, volume: 199, anno: 2000,
pagine: 77 - 83
SICI:
0378-5173(20000410)199:1<77:AOC(TC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBOXYVINYLPOLYMER INTERPOLYMER COMPLEX; POLYACRYLIC-ACID GEL; POLY(ETHYLENE OXIDE); SOLID DISPERSION; MEDICINE RELEASE; PHARMACEUTICAL INTERACTIONS; HYDROXYPROPYL CELLULOSE; RECTAL ABSORPTION; DOSAGE FORMS; ENHANCEMENT;
Keywords:
Carbopol (R); coating material; controlled release; cross-linking; spray mist; swelling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Muramatsu, M Kissei Pharmaceut Co Ltd, Pharmaceut Labs, 4365-1 Kashiwabara, Nagano 3998304, Japan Kissei Pharmaceut Co Ltd 4365-1 Kashiwabara NaganoJapan 3998304
Citazione:
M. Muramatsu et al., "Application of Carbopol (R) to controlled release preparations I. Carbopol(R) as a novel coating material", INT J PHARM, 199(1), 2000, pp. 77-83

Abstract

We investigated the application of Carbopol(R) (CP) as a novel coating material prepared with various grades of CP having different degrees of cross-linking and molecular weights. Viscosity and spray mist size of CP aqueous solutions at various concentrations of CP were measured. Core tablets containing theophylline (TP), as a model drug, were coated with CP at various coating ratios. The TP release profile from the CP-coated tablets was studiedby the JP13 paddle method. CP tablets were prepared by compressing CP powder, and the swelling behavior of the CP tablets in JP 1st fluid, purified water, and JP 2nd fluid was observed. The spray mist size of all CP aqueous solutions was small at a concentration of 1% and below, and drastically increased over a concentration of 1%. This result suggests that the appropriate concentration of the CP solution for coating is 1% or below. Sustained release of TP from the CP-coated tablets at a coating ratio of only 3% was observed in the JP 1st fluid and purified water, although fast release was observed in the JP 2nd fluid. The fast release in the latter fluid may be dueto the fact that CP is an acid material. These results suggest that it is feasible to control the drug release by use of an extremely small amount ofCP coating and that CP is useful as a novel coating material. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:46:37