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Titolo:
Mapping PET-measured triamcinolone acetonide (TAA) aerosol distribution into deposition by airway generation
Autore:
Lee, ZG; Berridge, MS; Finlay, WH; Heald, DL;
Indirizzi:
Univ Hosp Cleveland, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 eland, Cleveland, OH 44106 USA Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Alberta, Edmonton, AB T6G 2G8, Canada Univ Alberta Edmonton AB Canada T6G 2G8 rta, Edmonton, AB T6G 2G8, Canada Rhone Poulenc Rorer, Clin Pharm & Pharmacokinet, Collegeville, PA 19426 USA Rhone Poulenc Rorer Collegeville PA USA 19426 Collegeville, PA 19426 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 1, volume: 199, anno: 2000,
pagine: 7 - 16
SICI:
0378-5173(20000410)199:1<7:MPTA(A>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRONCHIAL TREE; DIAMETER-BASED RECONSTRUCTION; ATTENUATION CORRECTION; PULMONARY DEPOSITION; BRANCHING PATTERN; LUNG MORPHOLOGY; MODEL; SPECT; QUANTIFICATION; CT;
Keywords:
aerosol; inhalation mapping; three-dimensional measurement; pulmonary deposition; dynamic analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, ZG Univ Hosp Cleveland, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 leveland, OH 44106 USA
Citazione:
Z.G. Lee et al., "Mapping PET-measured triamcinolone acetonide (TAA) aerosol distribution into deposition by airway generation", INT J PHARM, 199(1), 2000, pp. 7-16

Abstract

The three dimensional (3D) distribution of inhaled drugs was measured using Positron Emission Tomography (PET) (Berridge, M.S, Muswick, G.J., Lee, Z., Leisure, G.L., Nelson, A.D., Muzic, R.F. Jr., Miraldi, F., Heald, D.L., 1997. PET evaluation of Azmacort(R) ([C-11]triamcinolone acetonide) dose administration. J. Nucl. Med. 38 (5) Suppl., 4-5). Data analysis was based upon regional ratios or penetration indices. To improve the analytical usefulness and objectivity, labeled drug from dynamic PET images was mapped into 23 airway generations following a general framework from a SPECT-based methodology (Fleming, J.S., Nassim, M.A., Hashish: A.H., Bailey, A.G., Conway, J., Holgate, S., Halson, P., Moole, E., Martonen, T.B., 1995. Description ofpulmonary deposition of radiolabeled aerosol by airway generation using a conceptual three dimensional model of lung morphology. J. Aerosol Med. 8, 341-356). A recently developed airway network model was used in this study. Quantitative PET scans of [C-ll]triamcinolone acetonide distribution in thelung were determined following administration of Azmacort(R), a commercialmetered dose inhaler with an integrated spacer device. Distributions at varying time periods after drug administration were investigated to explore the dynamics and kinetics of the aerosolized drug. Initially, deposition of labeled drug on conducting airways (generations 1-14) was found to be higher than those on acinar airways (generation 15-23), 64% versus 36%. The distribution pattern changed slowly with time. By 47 min, 51% of the dose remaining in the lung was found on conducting airways while 49% was on acinar airways. This study illustrates the value of PET imaging for the evaluation and design of drug formulations. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:28:02