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Titolo:
The role of complement in the acquired immune response
Autore:
Nielsen, CH; Fischer, EM; Leslie, RGQ;
Indirizzi:
Univ So Denmark, Dept Microbiol & Immunol, DK-5000 Odense C, Denmark Univ So Denmark Odense Denmark C ol & Immunol, DK-5000 Odense C, Denmark Hop Broussais, INSERM, U430, F-75674 Paris, France Hop Broussais Paris France F-75674 , INSERM, U430, F-75674 Paris, France
Titolo Testata:
IMMUNOLOGY
fascicolo: 1, volume: 100, anno: 2000,
pagine: 4 - 12
SICI:
0019-2805(200005)100:1<4:TROCIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICULAR DENDRITIC CELLS; HUMAN-B-CELL; ALTERNATIVE PATHWAY ACTIVATION; HUMAN LYMPHOCYTES-B; FC-GAMMA-RIIB; SYSTEMIC LUPUS-ERYTHEMATOSUS; INDEPENDENT TYPE-2 ANTIGENS; T-DEPENDENT ANTIGEN; C3D RECEPTOR CR-2; ANTIBODY-RESPONSE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Leslie, RGQ Univ So Denmark, Dept Microbiol & Immunol, Winslowpk 21, DK-5000 Odense C,Denmark Univ So Denmark Winslowpk 21 Odense Denmark C dense C,Denmark
Citazione:
C.H. Nielsen et al., "The role of complement in the acquired immune response", IMMUNOLOGY, 100(1), 2000, pp. 4-12

Abstract

Studies over the past three decades have clearly established a central role for complement in the promotion of a humoral immune response. The primaryfunction of complement, in this regard, is to opsonize antigen or immune complexes for uptake by complement receptor type 2 (CR2, CD21) expressed on B cells, follicular dendritic cells (FDC) and some T cells. A variety of mechanisms appear to be involved in complement-mediated promotion of the humoral response. These include: enhancement of antigen (Ag) uptake and processing by both Ag-specific and non-specific B cells for presentation to specific T cells; the activation of a CD21/CD19 complex-mediated signalling pathway in B cells, which provides a stimulus synergistic to that induced by antigen interaction with the B-cell receptor (BCR); and promotion of the interaction between B cells and FDC, where C3d-bearing immune complexes participate in intercellular bridging. Finally, current studies suggest that CR2 may also play a role in the determination of B-cell tolerance towards self-antigens and thereby hold the key to the previously observed correlation between deficiencies of the early complement components and autoimmune disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:08:58