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Titolo:
Local angiotensin II and transforming growth factor-beta 1 in renal fibrosis of rats
Autore:
Sun, Y; Zhang, JK; Zhang, JQ; Ramires, FJA;
Indirizzi:
Univ Tennessee, Ctr Hlth Sci, Dept Med, Div Cardiovasc Dis, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 Cardiovasc Dis, Memphis, TN 38163 USA Univ Tennessee, Ctr Hlth Sci, Dept Internal Med, Div Cardiol, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 d, Div Cardiol, Memphis, TN 38163 USA
Titolo Testata:
HYPERTENSION
fascicolo: 5, volume: 35, anno: 2000,
pagine: 1078 - 1084
SICI:
0194-911X(200005)35:5<1078:LAIATG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME; OBSTRUCTIVE NEPHROPATHY; TISSUE; HEART; FAILURE; MYOFIBROBLASTS; PROGRESSION; ACTIVATION; EXPRESSION; RECEPTOR;
Keywords:
kidney; fibrosis; myofibroblasts; angiotensin II; growth substances; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Sun, Y Univ Tennessee, Ctr Hlth Sci, Dept Med, Div Cardiovasc Dis, 956 Court Ave,Room B310, Memphis, TN 38163 USA Univ Tennessee 956 Court Ave,Room B310 Memphis TN USA 38163 163 USA
Citazione:
Y. Sun et al., "Local angiotensin II and transforming growth factor-beta 1 in renal fibrosis of rats", HYPERTENSIO, 35(5), 2000, pp. 1078-1084

Abstract

Studies have demonstrated that local angiotensin II (Ang II) generation isenhanced in repairing kidney and that ACE inhibition or AT(1) receptor blockade attenuates renal fibrosis. The localization of ACE and Ang II receptors and their relationship to collagen synthesis in the injured kidney, however, remain uncertain. Using a rat model of renal injury with subsequent fibrosis created with chronic elevations in circulating aldosterone (ALDO), we examined the distribution and binding density of ACE and Ang II receptorsin repairing kidneys, as well as their anatomic relationship to transforming growth factor-beta 1 (TGF-beta 1) mRNA, type I collagen mRNA, collagen accumulation, and myofibroblasts. Two groups of animals (n=7 in each group) were studied: (1) normal rats served as controls, and (2) uninephrectomizedrats received ALDO (0.75 mu g/h SC) and 1% NaCl in drinking water for 6 weeks. Compared with control rats, in ALDO-treated rats we found (1) significantly (P<0.01) increased blood pressure, reduced plasma renin activity, andincreased plasma creatinine levels, (2) diffuse fibrosis in both renal cortex and medulla, (3) abundant myofibroblasts at these sites of fibrosis, (4) significantly increased (P<0.01) binding density of ACE and Ang II receptors (60% AT(1), 408 AT(2)) at the sites of fibrosis, and (5) markedly increased (P<0.01) expression of TGF-beta 1 and type I collagen mRNAs at these same sites. Thus, in this rat model of renal repair, the enhanced expressionof ACE, Ang II receptors, and TGF-beta 1 is associated with renal fibrosis. Ang II generated at the sites of repair appears to have autocrine/paracrine functions in the regulation of renal fibrous tissue formation alone or through its stimulation of TGF-beta 1 synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 08:43:10