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Titolo:
Relaxation in hypertrophic cardiomyopathy and hypertensive heart disease: relations between hypertrophy and diastolic function
Autore:
De Marchi, SF; Allemann, Y; Seiler, C;
Indirizzi:
Univ Hosp Bern, Swiss Cardiocasc Ctr Bern, CH-3010 Bern, Switzerland Univ Hosp Bern Bern Switzerland CH-3010 Bern, CH-3010 Bern, Switzerland
Titolo Testata:
HEART
fascicolo: 6, volume: 83, anno: 2000,
pagine: 678 - 684
SICI:
1355-6037(200006)83:6<678:RIHCAH>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; MYOCARDIAL VELOCITIES; ECHOCARDIOGRAPHY; NONUNIFORMITY; ABNORMALITIES; AMPLITUDES; DURATIONS; PATTERN; TIMINGS;
Keywords:
hypertrophic cardiomyopathy; hypertensive heart disease; isovolumetric relaxation; diastolic function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Seiler, C Univ Hosp Bern, Swiss Cardiocasc Ctr Bern, Freiburgstr, CH-3010 Bern, Switzerland Univ Hosp Bern Freiburgstr Bern Switzerland CH-3010 Switzerland
Citazione:
S.F. De Marchi et al., "Relaxation in hypertrophic cardiomyopathy and hypertensive heart disease: relations between hypertrophy and diastolic function", HEART, 83(6), 2000, pp. 678-684

Abstract

Aim-To determine the relation between the extent and distribution of left ventricular hypertrophy and the degree of disturbance of regional relaxation and global left ventricular filling. Methods-Regional wall thickness (rWT) was measured in eight myocardial regions in 17 patients with hypertrophic cardiomyopathy, 12 patients with hypertensive heart disease, and 10 age matched normal subjects, and an asymmetry index calculated. Regional relaxation was assessed in these eight regionsusing regional isovolumetric relaxation time (rIVRT) and early to late peak filling velocity ratio (rE/A) derived from Doppler tissue imaging. Asynchrony of rIVRT was calculated. Doppler left ventricular filling indices wereassessed using the isovolumetric relaxation time, the deceleration time ofearly diastolic filling (E-DT), and the E/A ratio. Results-There was a correlation between rWT and both rIVRT and rE/A in thetwo types of heart disease (hypertrophic cardiomyopathy: r = 0.47, p < 0.0001 for rIVRT; r -0.20, p < 0.05 for rE/A; hypertensive heart disease: r = 0.21, p < 0.05 for rIVRT; r = -0.30, p = 0.003 for rE/A). The degree of left ventricular asymmetry was related to prolonged E-DT (r = 0.50, p = 0.001)and increased asynchrony (r = 0.42, p = 0.002) in all patients combined, but not within individual groups. Asynchrony itself was associated with decreased EIA (r = -0.39, p = 0.01) and protracted E-DT (r = 0.69, p < 0.0001) and isovolumetric relaxation time (r = 0.51, p = 0.001) in all patients. These correlations were still significant for E-DT in hypertrophic cardiomyopathy (r = 0.56, p = 0.02) and hypertensive heart disease (r = 0.59, p < 0.05) and for isovolumetric relaxation time in non-obstructive hypertrophic cardiomyopathy (n = 8, r = 0.87, p = 0.005). Conclusions-Non-invasive ultrasonographic examination of the left ventricle shows that in both hypertrophic cardiomyopathy and hypertensive heart disease, the local extent of left ventricular hypertrophy is associated with regional left ventricular relaxation abnormalities. Asymmetrical distribution of left ventricular hypertrophy is indirectly related to global left ventricular early filling abnormalities through regional asynchrony of left ventricular relaxation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:08:53