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Titolo:
D-2-dopamine receptor upregulation and treatment response under neuroleptic therapy
Autore:
Schroder, J; Bubeck, B; Sauer, H;
Indirizzi:
Univ Heidelberg, Psychiat Klin, D-69115 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69115 , D-69115 Heidelberg, Germany Univ Heidelberg, Abt Nuklearmed, D-6900 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-6900 ed, D-6900 Heidelberg, Germany
Titolo Testata:
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
, volume: 68, anno: 2000, supplemento:, 1
pagine: S42 - S45
SICI:
0720-4299(200004)68:<S42:DRUATR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
GER
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; NEUROLOGICAL SOFT SIGNS; SCHIZOPHRENIC-PATIENTS; I-123 IODOBENZAMIDE; ABNORMAL MOVEMENTS; DOPAMINE-RECEPTORS; BASAL GANGLIA; HUMAN-BRAIN; OCCUPANCY; SUBSYNDROMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Schroder, J Univ Heidelberg, Psychiat Klin, Vossstr 4, D-69115 Heidelberg,Germany Univ Heidelberg Vossstr 4 Heidelberg Germany D-69115 Germany
Citazione:
J. Schroder et al., "D-2-dopamine receptor upregulation and treatment response under neuroleptic therapy", F NEUR PSYC, 68, 2000, pp. S42-S45

Abstract

Animal and post mortem studies indicate that neuroleptic therapy may induce D2-dopamine receptor upregulation in the basal ganglia. To address this phenomenon in a clinical study, we investigated the D2-dopamine receptor binding in 15 DSM-III-R schizophrenics in the drug-naive state and three days after completion of a standardized neuroleptic therapy (benperidol 12-16 mg/d for 25 days) using single photon emission computed tomography (SPECT). SPECT scans were obtained 2 h after intravenous injection of 185 MBq I-123-IBZM. For analysis, basal ganglia to frontal cortex (BG/FC) ratios were calculated and the patient sample was subgrouped into patients with a favourable versus a poor treatment response. Neuroleptic treatment led to decreased BG/FC ratios in patients with a favourable response, but increased ratios in the poor responders (df=1, F=4.1, p=0.06). Changes of BG/FC ratios were significantly correlated with extrapyramidal side effects, but not with neurological soft signs (NSS). Our findings indicate that neuroleptic therapy induces D2-dopamine receptor upregulation in a subgroup of patients characterized by poor treatment response and pronounced extrapyramidal side effects.

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Documento generato il 08/04/20 alle ore 12:13:12