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Titolo:
Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins
Autore:
Yao, Y; Doki, Y; Jiang, W; Imoto, M; Venkatraj, VS; Warburton, D; Santella, RM; Lu, BF; Yan, LB; Sun, XH; Su, T; Luo, JQ; Weinstein, IB;
Indirizzi:
Columbia Univ Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Sch Publ Hlth, Div Environm Hlth Sci, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Integrated Program CMBS, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Biol Sci, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA NYU, Med Ctr, Dept Cell Biol, New York, NY 10016 USA NYU New York NY USA 10016 Med Ctr, Dept Cell Biol, New York, NY 10016 USA
Titolo Testata:
EXPERIMENTAL CELL RESEARCH
fascicolo: 1, volume: 257, anno: 2000,
pagine: 22 - 32
SICI:
0014-4827(20000525)257:1<22:CACODA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOOP-HELIX PROTEIN; D-TYPE CYCLINS; PROMYELOCYTIC LEUKEMIA-CELLS; DNA-BINDING PROTEINS; TRANSCRIPTION FACTOR; MYELOID DIFFERENTIATION; NEGATIVE REGULATOR; ESTROGEN-RECEPTOR; GENE-EXPRESSION; RETINOBLASTOMA PROTEIN;
Keywords:
DIP1; cyclin D1; Id; HL60; differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Weinstein, IB Columbia Univ Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, 701 W 168th St,Room 1509, New York, NY 10032 USA Columbia Univ CollPhys & Surg 701 W 168th St,Room 1509 New York NY USA 10032
Citazione:
Y. Yao et al., "Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins", EXP CELL RE, 257(1), 2000, pp. 22-32

Abstract

Using human cyclin D1 as the "bait" in a yeast two-hybrid system, togetherwith a HL60 cDNA library, we identified a novel human nuclear protein designated DIP1. This protein is expressed in a variety of cell types, and in fibroblasts its level remains constant throughout the cell cycle. However, the level of this protein increases severalfold during the differentiation of HL60 cells. The DIP1 protein can be phosphorylated in vitro by a cellularkinase and this activity reaches its maximum in extracts obtained from cells in the G1 phase of the cell cycle. DIP1 contains a helix-loop-helix motif but lacks an adjacent basic DNA-binding domain, thus resembling the Id family of proteins. The dip1 gene is located on human chromosome 16p11.2-12, a locus that is amplified in several types of human cancer. These results suggest that DIP1 may be involved in the control of gene expression and differentiation, but its precise function remains to be determined. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:13:47