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Titolo:
G-CSF and IL-8 but not GM-CSF correlate with severity of pulmonary neutrophilia in acute respiratory distress syndrome
Autore:
Aggarwal, A; Baker, CS; Evans, TW; Haslam, PL;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Sch Med, Natl Heart & Lung Inst, Cell Biol Unit, London SW3 6LY, England Univ London Imperial Coll Sci Technol & Med London England SW3 6LY gland Univ London Imperial Coll Sci Technol & Med, Sch Med, Crit Care Unit, London SW3 6LY, England Univ London Imperial Coll Sci Technol & Med London England SW3 6LY gland
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 5, volume: 15, anno: 2000,
pagine: 895 - 901
SICI:
0903-1936(200005)15:5<895:GAIBNG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; ACUTE LUNG INJURY; INFLAMMATORY CYTOKINES; CHRONIC NEUTROPENIA; GRANULOCYTE; INTERLEUKIN-8; CELLS; ACCUMULATION; EXPRESSION; APOPTOSIS;
Keywords:
acute respiratory distress syndrome; granulocyte colony-stimulating factor; granulocyte macrophage colony-stimulating factor; interleukin-8; neutrophils; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Haslam, PL Univ London Imperial Coll Sci Technol & Med, Sch Med, Natl Heart & Lung Inst, Cell Biol Unit, Dovehouse St, London SW3 6LY, England Univ London Imperial Coll Sci Technol & Med Dovehouse St London England SW3 6LY
Citazione:
A. Aggarwal et al., "G-CSF and IL-8 but not GM-CSF correlate with severity of pulmonary neutrophilia in acute respiratory distress syndrome", EUR RESP J, 15(5), 2000, pp. 895-901

Abstract

Activated neutrophils play a major role in the pathogenesis of acute respiratory distress syndrome (ARDS), and persistence of pulmonary neutrophilia is related to poor survival. Interleukin (IL)-8 is implicated in recruitingneutrophils to the lungs but it has been postulated that granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulatingfactor (G-CSF), which can promote the survival of neutrophils by delaying apoptosis, may prolong the inflammatory response. The aim of this study wasto investigate the levels of GM-CSF and G-CSF in the lungs of patients with ARDS and determine their relationship relative to IL-8 with levels of neutrophils and clinical outcome. The lungs of 31 patients with ARDS were sampled by means of bronchoalveolar lavage (BAL) and assays of the three cytokines were conducted via enzyme-linked immunosorbent assay. GM-CSF, G-CSF and IL-8 were all increased in the patients compared to healthy controls but concentrations of GM-CSP were much lower than those of G-CSP and IL-8 (GM-CSF<G-CSF<IL-8). Levels of G-CSP and IL-8, but not GM-CSE; correlated strongly with each other (rs=0.86, p<0.001) and with BAL neutrophil counts, and only levels of G-CSF were significantly higher in nonsurvivors than survivors (p<0.05). This evidence indicates that granulocyte colony-stimulating factor as wellas interleukin-8 plays a role in the mechanisms of pulmonary neutrophilia in acute respiratory distress syndrome, whereas the role of granulocyte-macrophage colony-stimulating factor remains unclear. The higher levels of granulocyte colony-stimulating factor in nonsurvivors, together with previous reports that recombinant granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor occasionally induce acute lung injury, emphasize that the role of these mediators in pathogenesis needs to beelucidated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:43:48