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Titolo:
Lack of synergism between caffeine and SKF 38393 on rotational behavior in6-hydroxydopamine-denervated rats
Autore:
Casas, M; Prat, G; Rubio, A; Barbanoj, M; Jane, F;
Indirizzi:
Univ Autonoma Barcelona, Lab Neuropsicofarmacol, Inst Recerca Hosp Santa Creu & Sant Pau, Dept Psiquiatria, Barcelona 08025, Spain Univ Autonoma Barcelona Barcelona Spain 08025 ia, Barcelona 08025, Spain
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 396, anno: 2000,
pagine: 93 - 99
SICI:
0014-2999(20000519)396:2-3<93:LOSBCA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; ADENOSINE RECEPTORS; DOPAMINE D-1; LOCOMOTOR-ACTIVITY; INDUCED STIMULATION; DENERVATED RATS; TOLERANCE; METHYLXANTHINES; APOMORPHINE; BRAIN;
Keywords:
dopamine D-1 receptor; 6-hydroxydopamine; turning behavior; behavioral tolerance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Casas, M Univ Autonoma Barcelona, Lab Neuropsicofarmacol, Inst Recerca Hosp Santa Creu & Sant Pau, Dept Psiquiatria, Avgda St Antoni Ma Claret 167, Barcelona 08025, Spain Univ Autonoma Barcelona Avgda St Antoni Ma Claret 167Barcelona Spain 08025
Citazione:
M. Casas et al., "Lack of synergism between caffeine and SKF 38393 on rotational behavior in6-hydroxydopamine-denervated rats", EUR J PHARM, 396(2-3), 2000, pp. 93-99

Abstract

We have recently shown a synergistic effect between caffeine and the dopamine D-2 receptor agonist, bromocriptine, on contralateral rotational behavior in unilaterally 6-hydroxydopamine-denervated rats. In addition, we foundthat bromocriptine prevented caffeine-induced tolerance to this behavior following repeated treatment. In the present study, we investigated whether or not the dopamine D-1 receptor agonist, (+/-)-phenyl-2,3,4,5-tetrahydro-(1 H)-3-benzazepine-7,8-diol (SKF 38393), presented similar characteristics. Different groups of rats received simultaneous injections of either vehicle plus vehicle, caffeine (40 mg/kg) plus vehicle, SKF 38393 (0.5, 1, 2, and4 mg/kg) plus vehicle, or caffeine plus SKF 38393 (0.5, I, 2, and 4 mg/kg)for 5 consecutive days, and both ipsilateral and contralateral rotational behavior was measured. Results showed that, on the first day of treatment, caffeine produced significantly more rotational behavior than did a low dose of SKF 38393 (0.5 mg/kg), and significantly less turning than at higher doses (2 and 4 mg/kg). Combined treatment with caffeine and a high dose of SKF 38393 (4 mg/kg) produced significantly more rotational behavior than didcaffeine plus vehicle. With repeated administration, caffeine produced sustained tolerance to its effects on rotational behavior, whereas SKF 38393 did not. In the groups treated with low doses of SKF 38393 (0.5, and 1 mg/kg) plus caffeine, tolerance was observed while in the groups that received high doses of SKF 38393 (2 and 4 mg/kg) plus caffeine, no tolerance was observed to rotational behavior. These results suggest that maximal stimulationof dopamine D-1 receptors may be needed to prevent the tolerance effects of caffeine in this animal model. This finding may have clinical relevance to the therapeutic treatment of Parkinson's disease. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:20:51