Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Antinociceptive activity of combination of morphine and NMDA receptor antagonists depends on the inter-injection interval
Autore:
Belozertseva, IV; Dravolina, OA; Neznanova, ON; Danysz, W; Bespalov, AY;
Indirizzi:
Pavlov Med Univ, Inst Pharmacol, Dept Psychopharmacol, Lab Behav Pharmacol, St Petersburg 197089, Russia Pavlov Med Univ St Petersburg Russia 197089 St Petersburg 197089, Russia Merck & Co Inc, Dept Pharmacol Res, D-60318 Frankfurt, Germany Merck & Co Inc Frankfurt Germany D-60318 Res, D-60318 Frankfurt, Germany
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 396, anno: 2000,
pagine: 77 - 83
SICI:
0014-2999(20000519)396:2-3<77:AAOCOM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTOR; ANALGESIC TOLERANCE; OPIOID TOLERANCE; PAIN SENSITIVITY; GLYCINE SITE; SPINAL-CORD; IN-VITRO; RAT; MK-801; MICE;
Keywords:
morphine; antinociception; NMDA receptor antagonist; D-CPPene (SDZ EAA 494); memantine; MRZ 2/579; MRZ 2/576; ACEA-1021;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Bespalov, AY Pavlov Med Univ, Inst Pharmacol, Dept Psychopharmacol, Lab Behav Pharmacol, 6-8 Leo Tolstoy St, St Petersburg 197089, Russia Pavlov Med Univ 6-8 Leo Tolstoy St St Petersburg Russia 197089
Citazione:
I.V. Belozertseva et al., "Antinociceptive activity of combination of morphine and NMDA receptor antagonists depends on the inter-injection interval", EUR J PHARM, 396(2-3), 2000, pp. 77-83

Abstract

The actual time-course of morphine antinociception is shorter than what would be predicted from its elimination kinetics, suggesting the presence of an acute tolerance phenomenon. Since antagonists acting at NMDA subtype of glutamate receptors were repeatedly shown to prolong acute morphine antinociception, acute tolerance may be attributed to hyperactivity of NMDA receptors. The ability of various site-selective NMDA receptor antagonists to affect morphine antinociception (tail-flick test) was assessed in mice 30 and 120 min after acute morphine challenge. Competitive NMDA receptor antagonist 3-(2-carboxypiperazin-4-yl)-1-propenyl-1-phosphonic acid (D-CP-Pene) (SDZEAA 494; 0.1-1 mg/kg), low-affinity channel blockers 1-amino-3,5-dimethyl adamantane (memantine) (1-10 mg/kg) and 1-amino-1,3,3,5,5-pentamethyl-cyclohexan hydrochloride (MRZ 2/579) (1-10 mg/kg), glycine site antagonists 5-nitro-6,7-dichloro1,4-dihydro-2,3-quinoxalinedione (ACEA-1021) (5 or 10 mg/kg) and 8-chloro-4-hydroxy-1-oxo-1,2-dihydropyridaliono(4,5-b)quinoline- 5-oxide choline salt (MRZ 2/576) (1-10 mg/kg) were administered intraperitoneally (i.p.) 15 or 30 min prior to the tail-flick test (i.e., interval betweeninjections of morphine and NMDA receptor antagonist was either 0-15 or 90-105 min). ACEA-1021, MRZ 2/576 and to the lesser extent, memantine and MRZ 2/579 enhanced morphine antinociception when tests were conducted 120 but not 30 min post-morphine. D-CPPene potentiated morphine antinociception irrespective of the interval between morphine administration and the tail-flicktest. The results suggest that NMDA receptor antagonists may restore analgesic activity of morphine in acutely tolerant mice. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:46:12