Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Lipoproteins and low-dose estradiol replacement therapy in post-menopausalType 2 diabetic patients: the effect of addition of norethisterone acetate
Autore:
Owens, D; Collins, PB; Johnson, A; Tomkin, GH;
Indirizzi:
Trinity Coll, Dept Clin Med, Dublin, Ireland Trinity Coll Dublin Ireland rinity Coll, Dept Clin Med, Dublin, Ireland
Titolo Testata:
DIABETIC MEDICINE
fascicolo: 4, volume: 17, anno: 2000,
pagine: 308 - 315
SICI:
0742-3071(200004)17:4<308:LALERT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; CHOLESTERYL ESTER TRANSFER; CORONARY HEART-DISEASE; FATTY-ACID COMPOSITION; POSTMENOPAUSAL WOMEN; INSULIN-RESISTANCE; OXIDATION; ESTROGEN; 17-BETA-ESTRADIOL; PROGESTIN;
Keywords:
17-beta-estradiol; cell cholesterol; cholesteryl ester transfer protein; hormone replacement therapy; LDL fatty acids; lipoprotein composition; norethisterone acetate; plasma cholesterol; Type 2 diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Tomkin, GH 1 Fitzwilliam Sq, Dublin 2, Ireland 1 Fitzwilliam Sq Dublin Ireland 2 lliam Sq, Dublin 2, Ireland
Citazione:
D. Owens et al., "Lipoproteins and low-dose estradiol replacement therapy in post-menopausalType 2 diabetic patients: the effect of addition of norethisterone acetate", DIABET MED, 17(4), 2000, pp. 308-315

Abstract

Aims Low-dose continuous oestrogen/progestogen may increase patient compliance long-term but the cardioprotective effects in diabetes are unknown. The aim of this study was to compare the effect of low-dose oral oestrogen (1mg, 17-beta-estradiol) treatment with oestrogen (1 mg 17-beta-estradiol) in combination with low-dose (0.5 mg) continuous norethisterone acetate (NETA) on lipoproteins in Type 2 diabetic patients. Methods Thirty-four post-menopausal Type 2 diabetic patients in moderate control (mean haemoglobin A(1c) 7.7%) who had a serum oestradiol level of < 50 pg/ml were examined over a 6-month period. Serum lipids, and lipoproteincomposition of very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) were measured. Serum lipoprotein(a) was determined by an ELISA method, LDL fatty acids by gas-liquid chromatography and LDL oxidizability by thiobarbituric acid reactive substances (TBARS assay). Cholesteryl eater transfer protein (CETP), and cell cholesterol were measured. Results There was a reduction in serum cholesterol on both treatments but no significant difference between treatment groups. LDL cholesterol decreased by 17% in each group. There was a no significant difference between the groups in serum VLDL or HDL cholesterol or serum triglycerides during the study. The change in lipoprotein(a) during the study was not significantly different between the groups. There was no significant difference in 4 h LDLoxidizability between groups. Although CETP increased with time in both groups there was no significant difference in the change between the groups. Conclusion In this small study, the addition of continuous low-dose NETA did not reduce the potentially beneficial effects of low-dose 17-beta-estradiol on the progression of atherosclerosis in diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:07:36