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Titolo:
The "typical" immunophenotype of acute promyelocytic leukemia (APL-M3): Does it prove true for the M3-variant?
Autore:
Exner, M; Thalhammer, R; Kapiotis, S; Mitterbauer, G; Knobl, P; Haas, OA; Jager, U; Schwarzinger, I;
Indirizzi:
Univ Vienna, Dept Lab Med, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 , Dept Lab Med, A-1090 Vienna, Austria Univ Vienna, Dept Med 1, Div Hematol & Hemostaseol, Vienna, Austria Univ Vienna Vienna Austria , Div Hematol & Hemostaseol, Vienna, Austria St Anna Childrens Hosp, Childrens Canc Res Inst, A-1090 Vienna, Austria StAnna Childrens Hosp Vienna Austria A-1090 nst, A-1090 Vienna, Austria
Titolo Testata:
CYTOMETRY
fascicolo: 2, volume: 42, anno: 2000,
pagine: 106 - 109
SICI:
0196-4763(20000415)42:2<106:T"IOAP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANS-RETINOIC ACID; ACUTE MYELOBLASTIC-LEUKEMIA; PML GENE BREAKPOINT; MYELOID-LEUKEMIA; CD2 EXPRESSION; MORPHOLOGY; DIAGNOSIS; VARIANT; BLASTS; ADULT;
Keywords:
acute promyelocytic leukemia; M3-variant; immunophenotype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Schwarzinger, I Univ Vienna, Dept Lab Med, Waehringerguertel 18-20, A-1090Vienna, Austria Univ Vienna Waehringerguertel 18-20 Vienna Austria A-1090
Citazione:
M. Exner et al., "The "typical" immunophenotype of acute promyelocytic leukemia (APL-M3): Does it prove true for the M3-variant?", CYTOMETRY, 42(2), 2000, pp. 106-109

Abstract

The immunophenotypes of 12 acute promyelocytic leukemias (APL-M3; eight hypergranular, four microgranular) with documented PML-RAR-alpha fusion gene are presented. Bone marrow mononuclear cells were immunophenotyped using a panel of 20 monoclonal antibodies. The hypergranular APLs exhibited a mature myeloid phenotype as it has been described to be typical for M3. No lineage infidelity was detectable in classic M3 cases. In contrast, among the four cases of M3 variant, all leukemias showed marked expression of CD34 and two of four cases expressed the HLA-DR antigen. The CD2 antigen was expressed in three of four cases. Furthermore, one case showed expression of the CD56 antigen, and one case was positive for the blood group H antigen. The data suggest that microgranular APL is a heterogeneous entity with regard tothe immunologic phonotype. Cytometry (Comm. Clin. Cytometry) 42:106-109, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:35:38