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Titolo:
Telemetric evaluation of body temperature and physical activity as predictors of mortality in a murine model of staphylococcal enterotoxic shock
Autore:
Vlach, KD; Boles, JW; Stiles, BG;
Indirizzi:
USA, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA USA Ft Detrick MD USA 21702 ct Dis, Vet Med Div, Ft Detrick, MD 21702 USA USA, Med Res Inst Infect Dis, Toxinol Div, Ft Detrick, MD 21702 USA USA Ft Detrick MD USA 21702 ct Dis, Toxinol Div, Ft Detrick, MD 21702 USA
Titolo Testata:
COMPARATIVE MEDICINE
fascicolo: 2, volume: 50, anno: 2000,
pagine: 160 - 166
SICI:
1532-0820(200004)50:2<160:TEOBTA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLUENZA-VIRUS INFECTION; TOXIC-SHOCK; CYTOKINE RELEASE; T-CELLS; IMMUNE-RESPONSE; HUMAN-DISEASE; B SEB; MICE; SUPERANTIGEN; HYPOTHERMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Vlach, KD USA, Med Res Inst Infect Dis, Vet Med Div, 1425 Porter St, Ft Detrick, MD 21702 USA USA 1425 Porter St Ft Detrick MD USA 21702 Detrick, MD 21702 USA
Citazione:
K.D. Vlach et al., "Telemetric evaluation of body temperature and physical activity as predictors of mortality in a murine model of staphylococcal enterotoxic shock", COMPAR MED, 50(2), 2000, pp. 160-166

Abstract

Background and Purpose: Hypothermia and death are used as experimental markers in murine models of staphylococcal enterotoxic shock. This study determined whether body temperature and physical activity, monitored telemetrically, could predict impending death and provide an earlier, more humane experimental endpoint. Methods: The study consisted of two iterations (experiments 1 and 2) to determine reproducibility of the model. Each experiment consisted of 24 BALB/c mice surgically implanted with intra-abdominal telemetry transmitters andthen injected intraperitoneally with sublethal or lethal doses of staphylococcal enterotoxin B (SEB) and/or lipopolysaccharide (LPS). Core body temperature and physical activity were continuously monitored in all mice for 10days before, and 5 days after, injections. Additionally, in experiment 2, subcutaneous temperatures were compared with core body temperatures obtained by telemetry. Results: Body temperature and physical activity were reduced in mice afteradministration of SEE and LPS, or LPS alone, but not SEB only. There was asignificant (P < 0.05) correlation between mortality and body temperature (P = 0.0077), but not physical activity (P = 0.97). Conclusion: Body temperature proved to be an early indicator of mortality in this murine model of staphylococcal enterotoxic shock.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:09:26