Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increases in cortical acetylcholine release during sustained attention performance in rats
Autore:
Himmelheber, AM; Sarter, M; Bruno, JP;
Indirizzi:
Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 ept Psychol, Columbus, OH 43210 USA Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 pt Neurosci, Columbus, OH 43210 USA
Titolo Testata:
COGNITIVE BRAIN RESEARCH
fascicolo: 3, volume: 9, anno: 2000,
pagine: 313 - 325
SICI:
0926-6410(200006)9:3<313:IICARD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTOR LIGANDS; BASAL FOREBRAIN; BEHAVIORAL VIGILANCE; CHOLINERGIC SYSTEMS; SENILE DEMENTIA; CORTEX; MODULATION; INFUSIONS; LESIONS; PHYSOSTIGMINE;
Keywords:
acetylcholine; sustained attention; microdialysis; cortex; basal forebrain; operant performance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Bruno, JP Ohio State Univ, Dept Psychol, 31 Townshend Hall,1885 Neil Ave, Columbus, OH 43210 USA Ohio State Univ 31 Townshend Hall,1885 Neil Ave Columbus OH USA 43210
Citazione:
A.M. Himmelheber et al., "Increases in cortical acetylcholine release during sustained attention performance in rats", COGN BRAIN, 9(3), 2000, pp. 313-325

Abstract

Acetylcholine (ACh) efflux in the frontoparietal cortex was studied with in vivo microdialysis while rats performed in an operant task designed to assess sustained attention. Transferring animals from the baseline environment into the operant chambers elicited a robust increase in cortical ACh efflux that persisted throughout the 18-min pre-task period. Subsequent performance in the 36-min sustained attention task was associated with further significant increases in frontoparietal ACh efflux. while the termination of the task resulted in a delayed decline in ACh levels. Upon the 12-min presentation of a visual distracter (flashing houselight, 0.5 Hz) during task performance, animals initially developed a significant response bias to the left lever in the first 6-min distracter block, reflecting a reduction of attentional effort. Under continued conditions of increased attentional demand, performance recovered during the second 6-min distracter block. This return to attentional processing was accompanied by an increase in cortical AChefflux, suggesting that the augmentation of attentional demand produced bythe distracter elicited further increases in ACh release. The enhancement of cortical ACh efflux observed prior to task performance implies the presence of complex relationships between cortical ACh release and anticipatory and/or contextual factors related to operant performance and attentional processing. This finding, along with the further increases in cortical ACh efflux associated with task performance, extends hypotheses regarding the crucial role of cortical cholinergic transmission for attentional functions. Furthermore, the effects of the distracter stimulus provide evidence for a direct relationship between attentional effort and cortical ACh release. (C)2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 23:12:07