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Titolo:
Glycosphingolipid component profiles or human gliomas - correlation to survival time and histopathological malignancy grading
Autore:
Becker, R; Rohlfs, J; Jennemann, R; Wiegandt, H; Mennel, HD; Bauer, BL;
Indirizzi:
Philipps Univ Hosp Marburg, Dept Neurosurg, Marburg, Germany Philipps UnivHosp Marburg Marburg Germany Neurosurg, Marburg, Germany Philipps Univ Hosp Marburg, Dept Neuropathol, Marburg, Germany Philipps Univ Hosp Marburg Marburg Germany europathol, Marburg, Germany Philipps Univ Hosp Marburg, Dept Physiol Chem, Marburg, Germany Philipps Univ Hosp Marburg Marburg Germany ysiol Chem, Marburg, Germany
Titolo Testata:
CLINICAL NEUROPATHOLOGY
fascicolo: 3, volume: 19, anno: 2000,
pagine: 119 - 125
SICI:
0722-5091(200005/06)19:3<119:GCPOHG>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-TUMORS; ABERRANT GLYCOSYLATION; GANGLIOSIDES; ASTROCYTOMAS; EXPRESSION; 3'-ISOLM1; GD3;
Keywords:
glycosphingolipids grading; systems human; gliomas; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Becker, R Klinikum Phillips Univ, Neurochirurg Klin, Baldingerstr, D-35033Marburg, Germany Klinikum Phillips Univ Baldingerstr Marburg Germany D-35033 any
Citazione:
R. Becker et al., "Glycosphingolipid component profiles or human gliomas - correlation to survival time and histopathological malignancy grading", CLIN NEUR, 19(3), 2000, pp. 119-125

Abstract

Background: Glycosphingolipids (GSL) are expressed on the surface of neuroectodermal cells. The correlation of a variety of distinct GSL with different primary brain tumors has been demonstrated. Three distinct GSL-componentprofiles (GSL-types I, II and III) of human gliomas have been defined by our group. The purpose of this study was to evaluate the correlation of the established GSL-types I-III with survival time and histopathological malignancy grading in 40 human gliomas. Methods: Neutral and acidic GSL-componentpatterns, histopathological malignancy grade and survival time, and a number of other relevant variables were examined. Kaplan-Meier survival curves were analyzed with the log rank test. Results: GSL-type I was expressed in 18 tumors (17 Glioblastoma multiforme (GBM) and 1 anaplastic astrocytoma (AA)). GSL-type II was expressed in 11 tumors (7 GEM, 3 AA, 1 low grade astrocytoma(LGA)). 10 patients presented with GSL-type III (3 GEM, 4 AA, 3 LGA). Kaplan Meier survival curves of GSL-types I-III differed significantly (p = 0.0231, log-rank-test). However, survival time correlated better to the WHO grades. Within a given malignancy grade, GSL-types gave additional informations about the proliferative properties. Conclusions: This is the first report of a correlation between survival time and human glioma neutral and acidic GSL-components. The results are in agreement with observations of other investigators. The analysis of GSL-type expression might give useful additional information about proliferative properties of human gliomas in a given malignancy grade. In particular, the early prediction of outcomes in anaplastic or low grade gliomas might be possible.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 16:39:39