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Titolo:
Tc-99m-N-NOET myocardial uptake reflects myocardial blood flow and not viability in dogs with reperfused acute myocardial infarction
Autore:
Vanzetto, G; Glover, DK; Ruiz, M; Calnon, DA; Pasqualini, R; Watson, DD; Beller, GA;
Indirizzi:
Univ Virginia, Hlth Sci Ctr, Dept Med, Div Cardiovasc,Expt Cardiol Lab, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Cisbio Int, Gif Sur Yvette, France Cisbio Int Gif Sur Yvette FranceCisbio Int, Gif Sur Yvette, France
Titolo Testata:
CIRCULATION
fascicolo: 20, volume: 101, anno: 2000,
pagine: 2424 - 2430
SICI:
0009-7322(20000523)101:20<2424:TMURMB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEXAKIS 2-METHOXYISOBUTYL ISONITRILE; CORONARY-OCCLUSION; CLEARANCE KINETICS; TL-201; PERFUSION; CELLS; TECHNETIUM-99M-TEBOROXIME; THROMBOLYSIS; NOET; ACCUMULATION;
Keywords:
radioisotopes; myocardial infarction; thallium; technetium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Glover, DK Univ Virginia, Hlth Sci Ctr, Dept Med, Div Cardiovasc,Expt Cardiol Lab, Box 500, Charlottesville, VA 22908 USA Univ Virginia Box 500 Charlottesville VA USA 22908 VA 22908 USA
Citazione:
G. Vanzetto et al., "Tc-99m-N-NOET myocardial uptake reflects myocardial blood flow and not viability in dogs with reperfused acute myocardial infarction", CIRCULATION, 101(20), 2000, pp. 2424-2430

Abstract

Background-N-Ethoxy-N-ethyl-dithiocarbato-nitrido-Tc-99m(Tc-99m-N-NOET) isa new neutral lipophilic Tc-99m-labeled myocardial perfusion agent with a high first-pass extinction fraction and delayed redistribution kinetics after transient ischemia comparable to what is observed with Tl-201. It is unknown whether the uptake of this tracer reflects myocardial viability or just reperfusion flow in the setting of a reperfused myocardial infarction. Methods and Results-In 13 anesthetized open-chest dogs, the left anterior descending coronary artery was occluded for 180 minutes, followed by 180 minutes of reperfusion. Tl-201 and Tc-99m-N-NOET were injected after either 60 (group 1, n = 9) or 175 (group 2, n = 4) minutes of reperfusion. Myocardial blood flow was measured by radioactive microspheres, and Tl-201 and Tc-99m-N-NOET tissue activities were determined by gamma-well counting. Normalized myocardial blood flow in the central infarct zone fell from 0.80 +/- 0.03 (SEM) and 0.89 +/- 0.01 at baseline to 0.18 +/- 0.04 and 0.13 +/- 0.02 during the occlusion in groups 1 and 2, respectively. Normalized Tl-201 activity in these segments was 0.39 +/- 0.04 and 0.43 +/- 0.04 and reflected myocardial viability rather than reperfusion flow (P<0.001), Normalized Tc-99m-N-NOET activity in the same segments was 0.84 +/- 0.08 and 0.64 +/- 0.03,respectively (P<0.01 versus Tl-201; P=NS versus reperfusion flow) and moreaccurately reflected reperfusion Row (0.99 +/- 0.17 and 0.70 +/-0.04) thanresidual viability. Conclusions-The myocardial uptake of Tc-99m-N-NOET reflects reperfusion myocardial blood now and not viability in a canine model of reperfused acute myocardial infarction. The clinical use of early Tc-99m-N-NOET imaging to assess the success of coronary reperfusion in patients with acute myocardialinfarction should be investigated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 19:51:27