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Titolo:
CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors
Autore:
Chinetti, G; Gbaguidi, FG; Griglio, S; Mallat, Z; Antonucci, M; Poulain, P; Chapman, J; Fruchart, JC; Tedgui, A; Najib-Fruchart, J; Staels, B;
Indirizzi:
Inst Pasteur Lille, INSERM, U325, Dept Atherosclerose, F-59019 Lille, France Inst Pasteur Lille Lille France F-59019 osclerose, F-59019 Lille, France Univ Lille 2, Fac Pharm, F-59800 Lille, France Univ Lille 2 Lille FranceF-59800 le 2, Fac Pharm, F-59800 Lille, France Hop La Pitie Salpetriere, INSERM, U321, Paris, France Hop La Pitie Salpetriere Paris France iere, INSERM, U321, Paris, France Hop Lariboisiere, INSERM, U141, F-75475 Paris, France Hop Lariboisiere Paris France F-75475 NSERM, U141, F-75475 Paris, France
Titolo Testata:
CIRCULATION
fascicolo: 20, volume: 101, anno: 2000,
pagine: 2411 - 2417
SICI:
0009-7322(20000523)101:20<2411:CIEIAL>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; MONOCYTE-DERIVED MACROPHAGES; CELLULAR CHOLESTEROL EFFLUX; B TYPE-I; SCAVENGER RECEPTOR; SR-BI; PPAR-GAMMA; ALPHA; CELLS; CLONING;
Keywords:
receptors; atherosclerosis; plaque; lipoproteins; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Staels, B Inst Pasteur Lille, INSERM, U325, Dept Atherosclerose, 1 Rue Calmette BP245, F-59019 Lille, France Inst Pasteur Lille 1 Rue Calmette BP245 Lille France F-59019 ce
Citazione:
G. Chinetti et al., "CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors", CIRCULATION, 101(20), 2000, pp. 2411-2417

Abstract

Background-The scavenger receptors are cell-surface receptors for native and modified lipoproteins that play a critical role in the accumulation of lipids by macrophages. CLA-1/SR-BI binds HDL with high affinity and is involved in the cholesterol reverse-transport pathway. Peroxisome proliferator-activated receptors (PPARs) are transcription factors regulating the expression of genes implicated in lipid metabolism, cellular differentiation, and inflammation. Here, we investigated the expression of CLA-1/SR-BI in macrophages and its regulation by PPARs. Methods and Results-CLA-1 is undetectable in human monocytes and is induced upon differentiation into macrophages. Immunohistological analysis on human atherosclerotic lesions showed high expression of CLA-1 in macrophages of the lipid core colocalizing with PPAR alpha and PPAR gamma staining. Activation of PPAR alpha and PPAR gamma resulted in the induction of CLA-1 protein expression in monocytes and in differentiated macrophages. Finally, SR-BI expression is increased in atherosclerotic lesions of apoE-null mice treated with either PPAR gamma or PPAR alpha ligands. Conclusions-Our data demonstrate that CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and induced by PPAR activation, identifying a potential role for PPARs in cholesterol homeostasis in atherosclerotic lesionmacrophages.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 18:13:08