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Titolo:
Immunolocalization of connexin 26 in the developing mouse cochlea
Autore:
Frenz, CM; Van De Water, TR;
Indirizzi:
Yeshiva Univ Albert Einstein Coll Med, Dept Otolaryngol, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 nx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 nx, NY 10461 USA
Titolo Testata:
BRAIN RESEARCH REVIEWS
fascicolo: 1, volume: 32, anno: 2000,
pagine: 172 - 180
SICI:
0165-0173(200004)32:1<172:IOC2IT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAP JUNCTION PROTEIN; DEVELOPMENTAL REGULATION; SENSORINEURAL DEAFNESS; EXPRESSION; COMMUNICATION; MUTATIONS; MESSENGER; PATTERNS; EMBRYOS; GENES;
Keywords:
development; cochlea; gap junction; connexin 26;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Van De Water, TR Yeshiva Univ Albert Einstein Coll Med, Dept Otolaryngol, 1410 Pelham Pkwy S,Kennedy Ctr Room 302, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med 1410 Pelham Pkwy S,Kennedy Ctr Room 302 Bronx NY USA 10461
Citazione:
C.M. Frenz e T.R. Van De Water, "Immunolocalization of connexin 26 in the developing mouse cochlea", BRAIN RES R, 32(1), 2000, pp. 172-180

Abstract

Gap junctions play a pivotal role in embryonic development by forming specialized regions of cell-cell communication. In this study, we demonstrate the temporal-spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea. Our results show localization of this gap junctionprotein to specific cochlear structures, including the inner and outer sulcus cells, the supporting cells of the inner hair cells, the mesenchyme derived portion of the stria vascularis, and the cells of the spiral ligament that interface with the basal cells of the stria vascularis. This suggests that this gap junction protein of served patterns of connexin 26 distribution is important for the differentiation and development of these structures(e.g., the role of the inner sulcus cells in producing the tectorial membrane). (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 01:37:07