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Titolo:
Glucocorticosteroids stimulate the activity of the promoters of peripheralmyelin protein-22 and protein zero genes in Schwann cells
Autore:
Desarnaud, F; Bidichandani, S; Patel, PI; Baulieu, EE; Schumacher, M;
Indirizzi:
INSERM, U488, F-94276 Le Kremlin Bicetre, France INSERM Le Kremlin Bicetre France F-94276 4276 Le Kremlin Bicetre, France Baylor Coll Med, Dept Neurol & Mol & Human Genet, Houston, TX 77034 USA Baylor Coll Med Houston TX USA 77034 & Human Genet, Houston, TX 77034 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 865, anno: 2000,
pagine: 12 - 16
SICI:
0006-8993(20000519)865:1<12:GSTAOT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR VIRUS PROMOTER; PROTEOLIPID PROTEIN; EXPRESSION; TRANSCRIPTION; GROWTH; ADRENALECTOMY; COOPERATION; RECEPTORS; ELEMENTS; ENHANCE;
Keywords:
glucocorticosteroids; dexamethasone; corticosterone; Schwann cells; myelin; P-0 and PMP22 gene promoters;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Desarnaud, F Univ Calif Irvine, Dept Pharmacol, 360 Med Surge 2, Irvine, CA 92697 USA Univ Calif Irvine 360 Med Surge 2 Irvine CA USA 92697 697 USA
Citazione:
F. Desarnaud et al., "Glucocorticosteroids stimulate the activity of the promoters of peripheralmyelin protein-22 and protein zero genes in Schwann cells", BRAIN RES, 865(1), 2000, pp. 12-16

Abstract

To better understand the mechanism by which glucocorticosteroids (GLUC) could enhance myelination in the PNS, cultured rat Schwann cells were transiently transfected with reporter constructs in which luciferase expression was controlled by the promoter region of either the peripheral myelin protein-22 (PMP22) or the protein zero (P-0) genes. GLUC stimulated the activity of the P-0 promoter and the PMP22 promoters 1 and 2. The effect of GLUC was specific as estradiol and testosterone did not activate the promoters. The antagonist RU486 did not abolish the effect of GLUC, but instead stimulatedpromoter activities by itself. In the mammary carcinoma cell line 34i, which expresses GLUC receptors, GLUC did not stimulate the P-0 and PMP22 promoters while the promoter of the mouse mammary tumor virus was strongly activated. Thus, the activation by GLUC of the promoter activities of two peripheral myelin protein genes is Schwann cell-specific. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:43:06