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Titolo:
The effect of steroid sulfatase inhibition on learning and spatial memory
Autore:
Johnson, DA; Wu, TH; Li, PK; Maher, TJ;
Indirizzi:
Duquesne Univ, Grad Sch Pharmaceut Sci, Div Pharmacol & Toxicol, Pittsburgh, PA 15282 USA Duquesne Univ Pittsburgh PA USA 15282 & Toxicol, Pittsburgh, PA 15282 USA Massachusetts Coll Pharm & Hlth Sci, Div Pharmaceut Sci, Boston, MA 02115 USA Massachusetts Coll Pharm & Hlth Sci Boston MA USA 02115 ton, MA 02115 USA Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 armacognosy, Columbus, OH 43210 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 865, anno: 2000,
pagine: 286 - 290
SICI:
0006-8993(20000526)865:2<286:TEOSSI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROSTEROID DEHYDROEPIANDROSTERONE-SULFATE; MICE; ACETYLCHOLINE; PREGNENOLONE; MODULATORS; RETENTION; RECEPTOR; RELEASE; DHEAS; BRAIN;
Keywords:
DHEAS; Morris water maze; steroid sulfatase inhibitor; learning and memory; neurosteroid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, DA Duquesne Univ, Grad Sch Pharmaceut Sci, Div Pharmacol & Toxicol, Pittsburgh, PA 15282 USA Duquesne Univ Pittsburgh PA USA 15282 ittsburgh, PA 15282 USA
Citazione:
D.A. Johnson et al., "The effect of steroid sulfatase inhibition on learning and spatial memory", BRAIN RES, 865(2), 2000, pp. 286-290

Abstract

Steroid sulfatase inhibitors can enhance the concentration of the neurosteroid DHEAS in rat brain. Previous studies have demonstrated that the steroid sulfatase inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine (DU-14) could reverse scopolamine induced amnesia in rats in a passive avoidance memoryparadigm. The intent of this study was to determine whether chronic pretreatment with DU-14 could reverse scopolamine amnesia and/or enhance spacial memory in the place, probe and cued versions of the Morris water maze (MWM). Rats were divided into four groups and administered IF for 15 days eitherDU-14 (30.0 mg/Kg) or corn oil (1.0 ml/Kg) vehicle. On training days animals were administered either scopolamine (1.0 mg/Kg) or saline (1.0 ml/Kg). The groups administered DU-14 displayed a significant enhancement in learning and spacial memory in the place version of the MWM, when compared to respective vehicle-scopolamine and vehicle-saline groups. In the probe version, the DU-14-saline group remained in the target quadrant of the maze significantly longer than any of the other groups indicating enhanced retention. In the cued version of the MWM, treatment with DU-14 did not significantly change escape latency suggesting that the steroid sulfatase inhibitor did not alter motivation or locomotion. These results suggest that the chronic administration of steroid sulfatase inhibitors enhance learning and spatial memory in rats. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

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Documento generato il 09/04/20 alle ore 20:05:53