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Titolo:
G-CSF reduces IFN-gamma and IL-4 production by T cells after allogeneic stimulation by indirectly modulating monocyte function
Autore:
Nawa, Y; Teshima, T; Sunami, K; Hiramatsu, Y; Maeda, Y; Yano, T; Shinagawa, K; Ishimaru, F; Omoto, E; Harada, M;
Indirizzi:
Okayama Univ, Sch Med, Dept Med 2, Okayama, Japan Okayama Univ Okayama Japan ma Univ, Sch Med, Dept Med 2, Okayama, Japan
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 10, volume: 25, anno: 2000,
pagine: 1035 - 1040
SICI:
0268-3369(200005)25:10<1035:GRIAIP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERSUS-HOST DISEASE; BLOOD STEM-CELLS; BONE-MARROW TRANSPLANTATION; PERIPHERAL-BLOOD; MONONUCLEAR-CELLS; PROGENITOR CELLS; HEMATOLOGIC MALIGNANCIES; ALLOANTIGEN STIMULATION; IMMUNE RECONSTITUTION; INTERLEUKIN-10;
Keywords:
G-CSF; IFN-gamma; IL-4; PBSCT; T cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Nawa, Y Ehime Prefectural Cent Hosp, 83 Kasuga Cho, Matsuyama, Ehime 7900024, Japan Ehime Prefectural Cent Hosp 83 Kasuga Cho Matsuyama Ehime Japan 7900024
Citazione:
Y. Nawa et al., "G-CSF reduces IFN-gamma and IL-4 production by T cells after allogeneic stimulation by indirectly modulating monocyte function", BONE MAR TR, 25(10), 2000, pp. 1035-1040

Abstract

Despite a 10-fold increase of T cell dose, the incidence and severity of acute GVHD following allogeneic transplantation of G-CSF-mobilized PBSC is not increased compared to BMT. Experimental murine studies demonstrate that G-CSF polarizes donor T cells toward a type 2 cytokine response. To determine whether G-CSF alters T cell cytokine responses, we investigated the effects of G-CSF administration on T cell proliferative and cytokine responses to alloantigen and Con A in nonadherent PBMC (NAC) and CD3(+) T cells obtained from normal individuals before and after G-CSF administration (10 mu g/kg x 4 days). Although T cell proliferative and cytokine (IFN-gamma and IL-4) responses to alloantigen stimulation and Con A were significantly reduced in post-G-CSF NAG, they were restored by the removal of non-T cells from post-G-CSF NAG. Furthermore, there was less T cell alloreactivity in MLR inthe presence of autologous post-G-CSF monocytes than in the presence of pre-G-CSF monocytes. This alteration was not replicated in vitro by culturingPBMC with G-CSF. These results suggest that G-CSF administration suppresses T cell proliferative and cytokine (IFN-gamma and IL-4) responses to allogeneic stimulation by indirectly modulating monocyte function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:08:32