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Titolo:
Parathyroid hormone and growth hormone have additive or synergetic effect when used as intervention treatment in ovariectomized rats with establishedosteopenia
Autore:
Mosekilde, L; Tornvig, L; Thomsen, JS; Orhii, PB; Banu, MJ; Kalu, DN;
Indirizzi:
Aarhus Univ, Inst Anat, Dept Cell Biol, DK-8000 Aarhus C, Denmark Aarhus Univ Aarhus Denmark C , Dept Cell Biol, DK-8000 Aarhus C, Denmark Univ Texas, Hlth Sci Ctr, Dept Physiol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 pt Physiol, San Antonio, TX 78284 USA
Titolo Testata:
BONE
fascicolo: 6, volume: 26, anno: 2000,
pagine: 643 - 651
SICI:
8756-3282(200006)26:6<643:PHAGHH>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERTEBRAL BONE MASS; ANTIRESORPTIVE AGENTS ESTROGEN; CORTICAL BONE; AGED RATS; SEX-DIFFERENCES; BIOMECHANICAL COMPETENCE; VOLUNTARY EXERCISE; SEXUALLY MATURE; SKELETAL SITES; TERM TREATMENT;
Keywords:
rat model; osteopenia; growth hormone (GH); parathyroid hormone (PTH); bone mass; bone strength; combination therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Mosekilde, L Aarhus Univ, Inst Anat, Dept Cell Biol, DK-8000 Aarhus C, Denmark Aarhus Univ Aarhus Denmark C iol, DK-8000 Aarhus C, Denmark
Citazione:
L. Mosekilde et al., "Parathyroid hormone and growth hormone have additive or synergetic effect when used as intervention treatment in ovariectomized rats with establishedosteopenia", BONE, 26(6), 2000, pp. 643-651

Abstract

The severely osteoporotic human skeleton is characterized by thin corticesand a very fragile cancellous framework. To increase the biomechanical competence of such a skeleton, powerful anabolic agents are needed. The aim ofthe present study was to compare the effect of parathyroid hormone (PTH), growth hormone (GH) and combination treatment with PTH and GH in an aged, rat model with established osteopenia. Furthermore, envelope- and site-specific effects of the two agents are described, Twelve-month-old virgin F334 rats were divided into sis groups with 11 animals per group: (1) baseline; (2) sham-operated + solvent vehicle (s.v. ) (sham); (3) ovariectomized + s.v. (ovx); (4) ovx + GH 2.5 mg/kg body weight per day; (5) ovx + PTH 80 mu g/kg body weight per day; and (6) ovx + GH and PTH treatment, Group 1 were killed to establish baseline values. Groups 2 (sham) and 3 (ovx) were killed after 24 weeks. Groups 4, 5, and 6 were allowed to develop osteopenia for 16weeks before treatment was initiated. Treatment was given for a period of 8 weeks, The effects of GH, PTH, and GH + PTH cotherapy were measured by biomechanical testing at four different skeletal sites: lumbar vertebra; femoral diaphysis; femoral neck; and distal femoral metaphysis. In addition, static histomorphometry was performed at the middiaphyseal region. Ovx induced a loss of bone strength at all sites, but this was significant only at the femoral diaphysis and distal metaphysis, GH could reverse the loss of strength at the diaphysis, but not at the metaphysis. PTH, on the other hand, reversed the loss of strength to values significantly over ovx at all four sites. At the metaphysis, PTH monotherapy increased strength to above sham levels. However, GH + PTH cotherapy showed additive or synergistic effects at the four tested sites, leading to strength values significantly over sham at all these sites. Static histomorphometry showed that GH exerted its main effect on the periosteal envelope and PTH on the endocortical envelope; for this reason, the GH + PTH combination treatment had an additive or synergistic effect. We conclude that GH and PTH have a very pronounced anaboliceffect when given in cotherapy, Therefore, this treatment regime seems promising in the clinical situation for management of patients with severe, established osteoporosis. (Bone 26:643-651; 2000) (C) 2000 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:33:54