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Titolo:
Posttranscriptional regulation of human leukocyte antigen G during human extravillous cytotrophoblast differentiation
Autore:
Copeman, J; Han, RNN; Caniggia, I; McMaster, M; Fisher, SJ; Cross, JC;
Indirizzi:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada Univ Toronto, Dept Obstet & Gynaecol, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 aecol, Toronto, ON M5G 1X5, Canada Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 Genet, Toronto, ON M5G 1X5, Canada Univ Calif San Francisco, Dept Stomatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco,CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco,CA 94143 USA
Titolo Testata:
BIOLOGY OF REPRODUCTION
fascicolo: 6, volume: 62, anno: 2000,
pagine: 1543 - 1550
SICI:
0006-3363(200006)62:6<1543:PROHLA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I MOLECULES; MAJOR HISTOCOMPATIBILITY COMPLEX; HUMAN TROPHOBLAST CELLS; HUMAN FIRST TRIMESTER; G MESSENGER-RNA; HLA-G GENE; INTRACELLULAR-TRANSPORT; PEPTIDE TRANSPORTER; PROTEIN EXPRESSION; TERM PLACENTA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Cross, JC Mt Sinai Hosp, Samuel Lunenfeld Res Inst, 600 Univ Ave, Toronto,ON M5G 1X5, Canada Mt Sinai Hosp 600 Univ Ave Toronto ON Canada M5G 1X5 1X5, Canada
Citazione:
J. Copeman et al., "Posttranscriptional regulation of human leukocyte antigen G during human extravillous cytotrophoblast differentiation", BIOL REPROD, 62(6), 2000, pp. 1543-1550

Abstract

Human maternal tolerance to a semiallogenic fetus may be maintained, in part, by the unusual expression pattern of antigen-presenting molecules in placental trophoblast cells. Extravillous cytotrophoblast (EVC) cells, which invade the maternal decidua, express high levels of human leukocyte antigenC (HLA-G), a nonclassical, major histocompatibility complex (MHC) class I molecule. HLA-C transcripts have been detected in tumors and other tissues,yet protein accumulation is rare. We show that, within EVC cells themselves, the mRNA is more broadly expressed than the protein. Specifically, accumulation of HLA-G protein was markedly delayed during EVC cell differentiation. To elucidate this mechanism, we performed a comprehensive analysis comparing the expression of HLA-G and proteins essential for MHC class I expression at the cell surface. The transporter for antigen processing proteins TAP1 and TAP2, as well as tapasin and beta(2)-microglobulin, appeared to be coordinately expressed throughout EVC cell columns. Strikingly, they all accumulated well in advance of the HLA-G protein but concurrently with its mRNA. A similar delay in the accumulation of the HLA-G protein was observed in vitro, using cultures of chorionic villi. We conclude that posttranscriptional regulation of HLA-G is fundamental to EVC cell development and is achieved independently of the peptide loading system. This represents a novel mechanism of MHC class I regulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:02:13