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Titolo:
A kinetic study of synthesis of amoxicillin using penicillin G acylase immobilized on agarose
Autore:
Goncalves, LRB; Fernandez-Lafuente, R; Guisan, JM; Giordano, RLC;
Indirizzi:
Univ Fed Sao Carlos, Dept Engn Quim, BR-13565905 Sao Carlos, SP, Brazil Univ Fed Sao Carlos Sao Carlos SP Brazil BR-13565905 BCCarlos, SP, Brazil Univ Fed Ceara, Dept Engn Quim, BR-60455766 Fortaleza, Ceara, Brazil Univ Fed Ceara Fortaleza Ceara Brazil BR-60455766 BCtaleza, Ceara, Brazil CSIC, Inst Catalisis & Petr Quim, Madrid 28049, Spain CSIC Madrid Spain 28049 Inst Catalisis & Petr Quim, Madrid 28049, Spain
Titolo Testata:
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
, volume: 84-6, anno: 2000,
pagine: 931 - 945
SICI:
0273-2289(200021)84-6:<931:AKSOSO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Keywords:
amoxicillin; kinetic model; penicillin G acylase; agarose; synthesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Giordano, RLC Univ Fed Sao Carlos, Dept Engn Quim, CP 676, BR-13565905 SaoCarlos, SP, Brazil Univ Fed Sao Carlos CP 676 Sao Carlos SP Brazil BR-13565905 BC
Citazione:
L.R.B. Goncalves et al., "A kinetic study of synthesis of amoxicillin using penicillin G acylase immobilized on agarose", APPL BIOC B, 84-6, 2000, pp. 931-945

Abstract

We present a kinetic model for the synthesis of amoxicillin from p-hydroxy-phenylgcine methyl ester and 6-aminopenicillanic acid, catalyzed by penicillin G acylase immobilized on agarose, at 25 degrees C. Michaelis-Menten kinetic parameters (with and without inhibition) were obtained from initial velocity data (FH 7.5 and 6.5). Amoxicillin synthesis reactions were used tovalidate the kinetic model after checking mass transport effects. A reasonable representation of this system was achieved under some operational conditions, but the model failed under others. Nevertheless, it will be useful whenever a simplified model is required, e.g., in model-based control algorithms for the enzymatic reactor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:49:23