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Titolo:
INHIBITION OF MATRIX METALLOPROTEINASE-1 BY DICHLOROMETHYLENE BISPHOSPHONATE (CLODRONATE)
Autore:
TERONEN O; KONTTINEN YT; LINDQVIST C; SALO T; INGMAN T; LAUHIO A; DING Y; SANTAVIRTA S; VALLEALA H; SORSA T;
Indirizzi:
UNIV HELSINKI,INST DENT,DEPT ORAL & MAXILLOFACIAL SURG,POB 41,MANNERHEIMINTIE 172 FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT PERIODONTOL FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT PEDODONT & ORTHODONT FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT MED FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT ORTHOPED & TRAUMATOL FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT ANAT FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT MED CHEM FIN-00014 HELSINKI FINLAND UNIV OULU,DEPT ORAL & MAXILLOFACIAL SURG & PATHOL SF-90220 OULU FINLAND ORTON INVALID FDN,RES UNIT HELSINKI FINLAND UNIV HELSINKI,DEPT SURG,DEPT ORAL & MAXILLOFACIAL SURG FIN-00014 HELSINKI FINLAND
Titolo Testata:
Calcified tissue international
fascicolo: 1, volume: 61, anno: 1997,
pagine: 59 - 61
SICI:
0171-967X(1997)61:1<59:IOMMBD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLAGENASE; BONE;
Keywords:
COLLAGENASE; INHIBITION; CLODRONATE/BIOPHOSPHONATE; BONE DESTRUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
O. Teronen et al., "INHIBITION OF MATRIX METALLOPROTEINASE-1 BY DICHLOROMETHYLENE BISPHOSPHONATE (CLODRONATE)", Calcified tissue international, 61(1), 1997, pp. 59-61

Abstract

Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate, The IC50 of clodronate to inhibit MMP-1 is 150 mu M. These findings suggest an extended and hitherto undescribed properties for clodronate/biphosphonates in prevention and treatment of tissue degradation in both bone and soft tissue destructive diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 12:20:46