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Titolo:
An address system in the vasculature of normal tissues and tumors
Autore:
Ruoslahti, E; Rajotte, D;
Indirizzi:
Burnham Inst, Canc Res Ctr, La Jolla, CA 92037 USA Burnham Inst La Jolla CA USA 92037 , Canc Res Ctr, La Jolla, CA 92037 USA
Titolo Testata:
ANNUAL REVIEW OF IMMUNOLOGY
, volume: 18, anno: 2000,
pagine: 813 - 827
SICI:
0732-0582(2000)18:<813:AASITV>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; DIPEPTIDYL PEPTIDASE-IV; MESENCHYMAL STEM-CELLS; VIVO PHAGE DISPLAY; ALPHA-V INTEGRINS; SIALYL-LEWIS-X; BINDING PEPTIDES; LYMPHATIC ENDOTHELIUM; FILAMENTOUS PHAGE; NG2 PROTEOGLYCAN;
Keywords:
homing; metastasis; angiogenesis; peptides; endothelial cells;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Ruoslahti, E Burnham Inst, Canc Res Ctr, La Jolla, CA 92037 USA Burnham Inst La Jolla CA USA 92037 r, La Jolla, CA 92037 USA
Citazione:
E. Ruoslahti e D. Rajotte, "An address system in the vasculature of normal tissues and tumors", ANN R IMMUN, 18, 2000, pp. 813-827

Abstract

The vasculature of individual tissues is highly specialized. The endothelium in lymphoid tissues expresses tissue-specific receptors for lymphocyte homing, and recent work utilizing phage homing has revealed an unprecedenteddegree of specialization in the vasculature of other normal tissues. In vivo screening of libraries of phage that displace random peptide sequences on their surfaces has yielded specific homing peptides for a large number ofnormal tissues. The tissue-specific endothelial molecules to which the phage peptides home may serve as receptors for metastasizing malignant cells. Probing of tumor vasculature has yielded peptides that home to endothelial receptors expressed selectively in angiogenic neovasculature. These receptors, and those specific fur the vasculature of individual normal tissues, are likely to be useful in targeting therapies to specific sites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 14:35:19