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Titolo:
Regulation of antibody responses via antibodies, complement, and Fc receptors
Autore:
Heyman, B;
Indirizzi:
Uppsala Univ, Dept Genet & Pathol, Uppsala, Sweden Uppsala Univ Uppsala Sweden Univ, Dept Genet & Pathol, Uppsala, Sweden
Titolo Testata:
ANNUAL REVIEW OF IMMUNOLOGY
, volume: 18, anno: 2000,
pagine: 709 - 738
SICI:
0732-0582(2000)18:<709:ROARVA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-AFFINITY RECEPTOR; FOLLICULAR DENDRITIC CELLS; COLLAGEN-INDUCED ARTHRITIS; HUMORAL IMMUNE-RESPONSE; B-MEMORY CELLS; MONOCLONAL IGG-ANTIBODIES; T-DEPENDENT ANTIGEN; RII-DEFICIENT MICE; COBRA VENOM FACTOR; LYMPHOCYTES-B;
Keywords:
immune complex; CD23; IgE; IgG; IgM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
175
Recensione:
Indirizzi per estratti:
Indirizzo: Heyman, B Uppsala Univ, Dept Genet & Pathol, Uppsala, Sweden Uppsala UnivUppsala Sweden t Genet & Pathol, Uppsala, Sweden
Citazione:
B. Heyman, "Regulation of antibody responses via antibodies, complement, and Fc receptors", ANN R IMMUN, 18, 2000, pp. 709-738

Abstract

Antibodies can completely suppress or enhance the antibody response to their specific antigen by several hundredfold. Immunoglobulin M (IgM) enhancesantibody responses via the complement system, and complement activation byIgM probably starts the chain of events leading to antibody responses to suboptimal antigen doses. Ige can enhance primary antibody responses in the absence of the complement system and seems to be dependent on Fc receptors for IgG (Fc gamma Rs). IgE enhances antibody responses via the low-affinityreceptor for IgE (Fc epsilon RII/CD3). The precise effector mechanisms that cause enhancement are not known, but direct B-cell signaling, antigen presentation, and increased follicular localization are all possibilities. IgC, IgE, and IgM may also suppress antibody responses when used in certain immunization regimes, and it seems reasonable that an important mechanism behind suppression is the masking of antigenic epitopes by antibodies. In addition, Fc gamma RIIB, which contains a cytoplasmic inhibitory motif, acts asa negative regulator of antibody responses. This receptor, however, may prevent the antibody responses from exceeding a certain level rather than causing complete suppression.

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Documento generato il 01/12/20 alle ore 01:04:53