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Titolo:
Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex
Autore:
Fearon, DT; Carroll, MC;
Indirizzi:
Univ Cambridge, Sch Clin Med, Dept Med, Wellcome Trust Immunol Unit, Cambridge, England Univ Cambridge Cambridge England Trust Immunol Unit, Cambridge, England Harvard Univ, Sch Med, Dept Pathol, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 hol, Ctr Blood Res, Boston, MA 02115 USA
Titolo Testata:
ANNUAL REVIEW OF IMMUNOLOGY
, volume: 18, anno: 2000,
pagine: 393 - 422
SICI:
0732-0582(2000)18:<393:ROBLRT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; RECEPTOR-MEDIATED ACTIVATION; SIGNAL-TRANSDUCTION MOLECULE; FOLLICULAR DENDRITIC CELLS; BRUTONS TYROSINE KINASE; HUMORAL IMMUNE-RESPONSE; T-DEPENDENT ANTIGEN; MONOCLONAL-ANTIBODY; GERMINAL-CENTERS; PHOSPHATIDYLINOSITOL 3-KINASE;
Keywords:
signal transduction; tolerance; costimulation; innate immunity; complement;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Fearon, DT Univ Cambridge, Sch Clin Med, Dept Med, Wellcome Trust Immunol Unit, Cambridge, England Univ Cambridge Cambridge England ol Unit, Cambridge, England
Citazione:
D.T. Fearon e M.C. Carroll, "Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex", ANN R IMMUN, 18, 2000, pp. 393-422

Abstract

The membrane protein complex CD19/CD21 couples the innate immune recognition of microbial antigens by the complement system to the activation of B cells. CD21 binds the C3d fragment of activated C3 that becomes covalently attached to targets of complement activation, and CD19 co-stimulates signaling through the antigen receptor, membrane immunoglobulin. CD21 is also expressed by follicular dendritic cells and mediates the long-term retention of antigen that is required for the maintenance of memory B cells. Understanding of the biology of this receptor complex has been enriched by analyses ofgenetically modified mice; these analyses have uncovered roles not only inpositive responses to foreign antigens, but also in the development of tolerance to self-antigens. Studies of signal transduction have begun to determine the basis for the coreceptor activities of CD 19. The integration of innate and adaptive immune recognition at this molecular site on the B cell guides the appropriate selection of antigen by adaptive immunity and emphasizes the importance of this coreceptor complex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:15:00