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Titolo:
POPULATION BIOLOGY OF LYMPHOCYTES: The flight for survival
Autore:
Freitas, AA; Rocha, B;
Indirizzi:
Inst Pasteur, Lymphocyte Populat Biol Unit, CNRS, URA 1961, F-75015 Paris,France Inst Pasteur Paris France F-75015 , CNRS, URA 1961, F-75015 Paris,France Inst Necker, INSERM, U345, F-75015 Paris, France Inst Necker Paris France F-75015 er, INSERM, U345, F-75015 Paris, France
Titolo Testata:
ANNUAL REVIEW OF IMMUNOLOGY
, volume: 18, anno: 2000,
pagine: 83 - 111
SICI:
0732-0582(2000)18:<83:PBOLTF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-CELL DEVELOPMENT; MEMORY T-CELLS; RECEPTOR TRANSGENIC MICE; CLASS-II MOLECULES; INDEPENDENT HOMEOSTATIC REGULATION; ADULT BONE-MARROW; IN-VIVO; POSITIVE SELECTION; ANTIGEN RECEPTOR; LIFE-SPAN;
Keywords:
lymphocyte survival and life spans; lymphocyte competition; lymphocyte homeostasis; naive and memory lymphocytes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
161
Recensione:
Indirizzi per estratti:
Indirizzo: Freitas, AA Inst Pasteur, Lymphocyte Populat Biol Unit, CNRS, URA 1961, 25Rue Dr Roux, F-75015 Paris, France Inst Pasteur 25 Rue Dr Roux Paris France F-75015 aris, France
Citazione:
A.A. Freitas e B. Rocha, "POPULATION BIOLOGY OF LYMPHOCYTES: The flight for survival", ANN R IMMUN, 18, 2000, pp. 83-111

Abstract

In this essay we suggest that the primary goal of the cells of the immune system is to ensure their own growth and survival. In adults, in steady-state conditions, the number and distribution of lymphocyte populations is under homeostatic control. New lymphocytes that are continuously produced in primary and secondary lymphoid organs must compete with resident cells for survival. We discuss recent findings supporting lymphocyte survival as a continuous active process and implicating cognate receptor engagement as fundamental survival signals for both T and B lymphocytes. The conflict of survival interests between different cell types gives rise to a pattern of interactions that mimics the behavior of complex ecological systems. In their flight for survival and in response to competition, lymphocytes use differentsurvival signals within different ecological niches during cell differentiation. This is the case for T and B lymphocytes and also for naive and memory/activated T and B cells. We discuss how niche differentiation allows theco-existence of different cell types and guarantees both repertoire diversity and efficient immune responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 02:59:11