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Titolo:
Olfactory disorders in Alzheimer's disease and Parkinson's disease: a review of the literature
Autore:
Nores, JM; Biacabe, B; Bonfils, P;
Indirizzi:
Univ Paris 05, Hop Raymond Poincare, Serv Med Interne, F-92380 Garches, France Univ Paris 05 Garches France F-92380 ed Interne, F-92380 Garches, France Univ Paris 05, Hop Boucicaut,Hosp Europeen G Pompidou, Fac Necker Enfants Malad, Serv ORL & Chirurg Cervico Faciale, Paris, France Univ Paris 05 Paris France ORL & Chirurg Cervico Faciale, Paris, France
Titolo Testata:
ANNALES DE MEDECINE INTERNE
fascicolo: 2, volume: 151, anno: 2000,
pagine: 97 - 106
SICI:
0003-410X(200003)151:2<97:ODIADA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
FRE
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; CENTRAL NERVOUS-SYSTEM; NEUROFIBRILLARY TANGLES; PATHOLOGICAL-CHANGES; ODOR IDENTIFICATION; SENILE PLAQUES; DEMENTIA; DYSFUNCTION; DEFICITS; HIPPOCAMPAL;
Keywords:
olfactory disorders; Alzheimer's disease; Parkinson's disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Nores, JM Univ Paris 05, Hop Raymond Poincare, Serv Med Interne, F-92380 Garches, France Univ Paris 05 Garches France F-92380 , F-92380 Garches, France
Citazione:
J.M. Nores et al., "Olfactory disorders in Alzheimer's disease and Parkinson's disease: a review of the literature", ANN MED IN, 151(2), 2000, pp. 97-106

Abstract

Olfactory disorders in Alzheimer's disease and Parkinson's disease ha ie been the topic of a large body of work over the last decades,Work devoted to olfactory disorders in Alzheimer's disease includes over 300 papers providing clinical and fundamental data. Anatomy studies in Alzheimer's disease have demonstrated a specific concentration of lesions in peripheral and central olfactory structures (senile plaques, neurofibrillary degeneration) as weil as lesions in layers II and III of the entorhinal cortex, These neuropathological findings led to the development of the hypothesis that olfactory disorders in Alzheimer's disease would result from a toxic process. Observed olfactory deficits involve both identification and recognition of odors and detection thresholds. Nevertheless, patients with Alzheimer's disease rarely consult for sensorial deficits as the other signs ofthe disease predominate. Neuropathology data on the olfactory system are much more sparse in Parkinson's disease. Lewy bodies suggestive of Parkinson's disease have been observed in the olfactory bulb and pathways, but, unlike Alzheimer's disease, the olfactory disorders appear to be stable, changing little over time, as opposed to the evolution of neurological symptoms and cognition impairment,Clinicians should be aware that olactory disorders are an integral part ofAlzheimer's disease and Parkinson's disease. Screening for sensorial impairment however is a secondary objective in the context of these neurodegenerative diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:13:14