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Titolo:
Quantitative comparison of intrabrain diffusion in adults and preterm and term neonates and infants
Autore:
Tanner, SF; Ramenghi, LA; Ridgway, JP; Berry, E; Saysell, MA; Martinez, D; Arthur, RJ; Smith, MA; Levene, MI;
Indirizzi:
Univ Leeds, Gen Infirm, Dept Med Phys, Leeds LS1 3EX, W Yorkshire, EnglandUniv Leeds Leeds W Yorkshire England LS1 3EX S1 3EX, W Yorkshire, England Univ Leeds, Gen Infirm, Ctr Med Imaging Res, Leeds LS1 3EX, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS1 3EX S1 3EX, W Yorkshire, England Univ Leeds, Leeds Gen Infirm, Ctr Reprod Growth & Dev, Leeds L2S 9NS, W Yorkshire, England Univ Leeds Leeds W Yorkshire England L2S 9NS 2S 9NS, W Yorkshire, England Univ Leeds, Leeds Gen Infirm, Dept Paediat Radiol, Leeds L2S 9NS, W Yorkshire, England Univ Leeds Leeds W Yorkshire England L2S 9NS 2S 9NS, W Yorkshire, England
Titolo Testata:
AMERICAN JOURNAL OF ROENTGENOLOGY
fascicolo: 6, volume: 174, anno: 2000,
pagine: 1643 - 1649
SICI:
0361-803X(200006)174:6<1643:QCOIDI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL BRAIN-DEVELOPMENT; CENTRAL-NERVOUS-SYSTEM; WEIGHTED MR; WHITE-MATTER; HUMAN STROKE; ANISOTROPY; COEFFICIENT; TENSOR; WATER; MYELINATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Tanner, SF Univ Leeds, Gen Infirm, Dept Med Phys, Wellcome Wing,Gt George St, Leeds LS1 3EX, W Yorkshire, England Univ Leeds Wellcome Wing,Gt George St Leeds W Yorkshire England LS1 3EX
Citazione:
S.F. Tanner et al., "Quantitative comparison of intrabrain diffusion in adults and preterm and term neonates and infants", AM J ROENTG, 174(6), 2000, pp. 1643-1649

Abstract

OBJECTIVE. Quantitative measurements of mean water diffusivity (D-av) weremade in human neonates, infants, and adults to assess changes in brain tissue that occur with maturation. SUBJECTS AND METHODS. Values of D-av were obtained by calculating the average of the diffusion measurements made with diffusion-sensitizing gradientsplaced along three orthogonal directions. The mean diffusivity, a rotationally invariant determination of apparent diffusion coefficient, was measured in five healthy prematurely born neonates and infants, in 10 healthy termneonates and infants, and in five adults. RESULTS. Values of D-av were found to decrease with maturation in most parts of the brain. In prematurely born neonates and infants with a postmenstrual age (postgestastional age + postnatal age) under 36 weeks, the average value of D-av in frontal white matter was 1.90 x 10(-3) mm(2) sec(-1). The corresponding value was measured as 1.62 x 10(-3) mm(2) sec(-1) in neonatesand infants born at term with a postnatal age of no more than 43 days and 0.79 x 10(-3) mm(2) sec(-1) in the adult brain. CONCLUSION. Values of D-av are known to decrease in neonates and young infants in the period immediately after ischemic insult. This decrease and theassociated increase in signal intensity seen on diffusion-weighted imaginghave been used to monitor ischemic brain injury in neonates and infants. Therefore, the decrease in D-av that occurs with maturation, which we reportin this study, must be considered if quantitative diffusion measurements are used to assess ischemic neonatal brain injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:31:47