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Titolo:
Induction of antigen-specific T cell responses in human volunteers after intranasal immunization with a whole-cell pertussis vaccine
Autore:
Berstad, AKH; Oftung, F; Korsvold, GE; Haugen, IL; Froholm, LO; Holst, J; Haneberg, B;
Indirizzi:
Natl Publ Hlth Inst, Dept Vaccinol, N-0403 Oslo, Norway Natl Publ Hlth Inst Oslo Norway N-0403 ept Vaccinol, N-0403 Oslo, Norway Natl Publ Hlth Inst, Dept Bacteriol, N-0403 Oslo, Norway Natl Publ Hlth Inst Oslo Norway N-0403 pt Bacteriol, N-0403 Oslo, Norway Univ Oslo, Inst Pharm, Dept Microbiol, Oslo, Norway Univ Oslo Oslo Norway iv Oslo, Inst Pharm, Dept Microbiol, Oslo, Norway
Titolo Testata:
VACCINE
fascicolo: 22, volume: 18, anno: 2000,
pagine: 2323 - 2330
SICI:
0264-410X(20000508)18:22<2323:IOATCR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS-INFECTION; MEMBRANE VESICLE VACCINE; BORDETELLA-PERTUSSIS; FILAMENTOUS HEMAGGLUTININ; MEDIATED-IMMUNITY; RESPIRATORY-INFECTION; CHOLERA-TOXIN; LYMPH-NODES; CHILDREN; LYMPHOCYTES;
Keywords:
human; nasal pertussis vaccine; T cell proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Berstad, AKH Natl Publ Hlth Inst, Dept Vaccinol, POB 4404 Torshov, N-0403 Oslo, Norway Natl Publ Hlth Inst POB 4404 Torshov Oslo Norway N-0403 rway
Citazione:
A.K.H. Berstad et al., "Induction of antigen-specific T cell responses in human volunteers after intranasal immunization with a whole-cell pertussis vaccine", VACCINE, 18(22), 2000, pp. 2323-2330

Abstract

We have studied the ability of an intranasally administered whole-cell pertussis vaccine (WCP) without adjuvant to induce antigen-specific T cell responses in humans. Six adult volunteers were given a vaccine dose (corresponding to 250 mu g protein) by nasal spray four times at weekly intervals, and peripheral blood mononuclear cells were assayed for antigen-specific proliferative T cell responses. All six vaccinees had a WCP-specific response, which in four of them remained elevated throughout the 2 month study. All participants also responded to the filamentous haemagglutinin (FHA) antigen,and four of them responded to inactivated pertussis toxin (PTd). A significant correlation between T cell proliferation against WCP and WCP-specific IgA antibody levels in nasal secretions was observed. This demonstrates that intranasal administration of a non-proliferating bacterial vaccine without any additional mucosal adjuvant can induce vaccine-specific T cell responses related to mucosal IgA secretion. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:17:49