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Titolo:
Wnt signalling in Caenorhabditis elegans: regulating repressors and polarizing the cytoskeleton
Autore:
Thorpe, CJ; Schlesinger, A; Bowerman, B;
Indirizzi:
Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ghes Med Inst, Seattle, WA 98195 USA Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Pharmacol, Seattle, WA 98195 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res Cambridge MA USA 02142 Cambridge, MA 02142 USA Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA Univ Oregon Eugene OR USA 97403 egon, Inst Mol Biol, Eugene, OR 97403 USA Univ Oregon, Dept Biol, Eugene, OR 97403 USA Univ Oregon Eugene OR USA 97403 v Oregon, Dept Biol, Eugene, OR 97403 USA
Titolo Testata:
TRENDS IN CELL BIOLOGY
fascicolo: 1, volume: 10, anno: 2000,
pagine: 10 - 17
SICI:
0962-8924(200001)10:1<10:WSICER>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-SHAPE CHANGES; GAP JUNCTIONAL COMMUNICATION; KINESIN-RELATED PROTEIN; BETA-CATENIN; C-ELEGANS; SIGNALING PATHWAY; DROSOPHILA GASTRULATION; DIVISION AXES; MAP KINASE; KAPPA-B;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Thorpe, CJ Univ Washington, Howard Hughes Med Inst, Box 357370, Seattle, WA 98195 USA Univ Washington Box 357370 Seattle WA USA 98195 e, WA 98195 USA
Citazione:
C.J. Thorpe et al., "Wnt signalling in Caenorhabditis elegans: regulating repressors and polarizing the cytoskeleton", TR CELL BIO, 10(1), 2000, pp. 10-17

Abstract

Wnt proteins are secreted, cysteine-rich glycoprotein ligands with numerous roles during animal development. Recent studies of endoderm induction during embryogenesis ill the nematode Caenorhabditis elegans challenge the prevailing view that Wnt signalling specifies cell fate by converting transcriptional repressors into activators. Instead, a mitogen-activated protein kinase (MAPK)-related pathway converges with Wnt signalling in C. elegans to relieve transcriptional repression. Futhermore, Wnt signalling induces endoderm in part by aligning the mitotic spindle in a responding cell along theanterior-posterior bony axis. To orient mitotic spindles, Wnt signalling might directly target the cytoskeleton, prior to any regulation of gene transcription in responding cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:17:17