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Titolo:
A novel HLA-B*40 allele and novel exon 1 sequences of two B*40 alleles identified in potential marrow donors
Autore:
Gourley, IS; Wu, J; Bassinger, S; Montoya, GD; Yee, J; Griffith, BB; Kearns, J; McKeen, M; Birkos, S; Williams, TM; Kamoun, M;
Indirizzi:
Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19035 USA Univ Penn Philadelphia PA USA 19035 & Lab Med, Philadelphia, PA 19035 USA Univ New Mexico, Dept Pathol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 athol, Albuquerque, NM 87131 USA
Titolo Testata:
TISSUE ANTIGENS
fascicolo: 4, volume: 55, anno: 2000,
pagine: 374 - 377
SICI:
0001-2815(200004)55:4<374:ANHAAN>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA;
Keywords:
HLA-B; polymerase chain reaction; DNA sequencing; bone marrow transplantation; bone marrow registry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Kamoun, M Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19035 USA Univ Penn Philadelphia PA USA 19035 Philadelphia, PA 19035 USA
Citazione:
I.S. Gourley et al., "A novel HLA-B*40 allele and novel exon 1 sequences of two B*40 alleles identified in potential marrow donors", TISSUE ANTI, 55(4), 2000, pp. 374-377

Abstract

Sequence-specific oligonucleotide probe hybridization and sequence-specific primer polymerase chain reaction (PCR) typing suggested the presence of variants of HLA-B*40 in three individuals. Two were part of 3,500 potential marrow donors being screened for the National Marrow Donor Program, while the third was a clinical specimen. PCR products encompassing HLA-B locus exons 1 through 3 were prepared and subcloned, In one individual, a native of the Pacific Islands, sequencing revealed a novel HLA-B*40 allele (B*4023), In two other individuals, a previously unknown exon 1 sequence was determined for KLA-B*4016 (ethnicity unknown) and B*4020 (Hispanic). These findingsfurther illustrate the substantial genetic variation present at the HLA-B locus within human populations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 18:47:09