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Titolo:
New therapies for heart failure: is thalidomide the answer?
Autore:
Davey, PP; Ashrafian, H;
Indirizzi:
Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Oxford OX3 9DY, England Univ Oxford Oxford England OX3 9DY eld Dept Med, Oxford OX3 9DY, England
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 5, volume: 93, anno: 2000,
pagine: 305 - 311
SICI:
1460-2725(200005)93:5<305:NTFHFI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; IDIOPATHIC DILATED CARDIOMYOPATHY; LEFT-VENTRICULAR DYSFUNCTION; FACTOR-ALPHA PRODUCTION; FAILING HUMAN HEART; CYTOKINE PRODUCTION; CIRCULATING LEVELS; FACTOR RECEPTORS; CARDIAC-FAILURE; TRANSGENIC MICE;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Davey, PP Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Oxford OX3 9DY, England Univ Oxford Oxford England OX3 9DY ed, Oxford OX3 9DY, England
Citazione:
P.P. Davey e H. Ashrafian, "New therapies for heart failure: is thalidomide the answer?", QJM-MON J A, 93(5), 2000, pp. 305-311

Abstract

The syndrome of advanced heart failure is associated with considerable morbidity and mortality. Ideas about the reasons for the progressive nature ofthe heart failure syndrome have changed over the years, with the initial view that progression was principally due to pump failure (the 'haemodynamic' hypothesis), giving way to move modern views, which implicate neuro-endocrine activation (including catecholamine excess, renin-angiotensin system activation, etc.). More recently, an excess of inflammatory cytokines has been found in advanced heart failure and implicated in the progression of thedisease. Amongst the cytokines found, TNF-alpha seems to be particularly important. The principle therapeutic action of thalidomide appears to be reduction of TNF-alpha levels. We therefore suggest that there may be a role for thalidomide, or its derivatives, in the management of advanced heart failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:59:56