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Titolo:
Characterisation of the effects of nicotine in the five-choice serial reaction time task in rats: antagonist studies
Autore:
Blondel, A; Sanger, DJ; Moser, PC;
Indirizzi:
Sanofi Synthelabo, F-92225 Bagneux, France Sanofi Synthelabo Bagneux France F-92225 helabo, F-92225 Bagneux, France
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 149, anno: 2000,
pagine: 293 - 305
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIHYDRO-BETA-ERYTHROIDINE; VENTRAL TEGMENTAL AREA; RECEPTOR ANTAGONIST; PHARMACOLOGICAL CHARACTERIZATION; ACETYLCHOLINE-RECEPTORS; NUCLEUS-ACCUMBENS; 6-HYDROXYDOPAMINE LESIONS; COGNITIVE PERFORMANCE; ATTENTIONAL FUNCTION; SUSTAINED ATTENTION;
Keywords:
nicotinic receptor; serial reaction time; methyllycaconitine; dihydro-beta-erythroidine; attention;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Moser, PC Sanofi Synthelabo, 31 Ave Paul Vaillant Couturier,BP 110, F-92225 Bagneux,France Sanofi Synthelabo 31 Ave Paul Vaillant Couturier,BP 110 Bagneux France F-92225
Citazione:
A. Blondel et al., "Characterisation of the effects of nicotine in the five-choice serial reaction time task in rats: antagonist studies", PSYCHOPHAR, 149(3), 2000, pp. 293-305

Abstract

Rationale: Nicotine has been shown to decrease reaction time and increase anticipatory responses in a five-choice serial reaction time task (5-CSRTT)in rats, but the receptor mechanisms mediating this effect remain unknown. Objectives: To evaluate further the effects of nicotine in this task and to characterise the receptors mediating these effects. Methods: Using a standard 5-CSRTT protocol, rats were trained to respond to a 0.5-s visual stimulus, which was reduced to 0.25 s for experimental sessions to induce a performance decrement. The effects of acute (0.03-0.3 mg/kg IF) and repeated (0.1 and 0.3 mg/kg IP for 5 days) nicotine were studied, as was the ability of mecamylamine (1 mg/kg IF), hexamethonium (5 mg/kg IF), dihydro-beta-erythroidine (6 mg/kg IF) and methyllycaconitine (10 mg/kg IF) to antagonise theeffects of acute nicotine. Results: Nicotine had no effect on accuracy, but decreased response latencies, improved performance in the less-well attended stimulus locations and increased inappropriate responding after both acute and repeated treatment. The data suggest that nicotine improves readiness to respond and improves target scanning, and decreases the ability to withhold premature responses (i.e. increased impulsivity). Except for the reduction in error latency, all of the effects of nicotine were antagonised bythe non-selective, centrally acting antagonist mecamylamine, whereas the peripheral antagonist hexamethonium had no effect, demonstrating that nicotine's actions are central in origin. Dihydro-beta-erythroidine, a competitive nicotinic antagonist, antagonised all of the effects of nicotine. In contrast, the a, antagonist methyllycaconitine had no significant effects against nicotine. Conclusions: These results demonstrate that the alpha(7) receptor subtype is not involved in the effects of nicotine in the 5-CSRTT and that its effects are more likely to be mediated by a receptor(s) such as alpha(4)beta(2), alpha(4)beta(4) and/or alpha(3)beta(2) which is sensitive to antagonism by dihydro-beta-erythroidine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:16:14