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Titolo:
Neonatal lead exposure impairs development of rodent barrel field cortex
Autore:
Wilson, MA; Johnston, MV; Goldstein, GW; Blue, ME;
Indirizzi:
Johns Hopkins Univ, Kennedy Krieger Inst, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 r Inst, Baltimore, MD 21205 USA Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Dept Pediat, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Pediat, Baltimore, MD 21205 USA Johns Hopkins Univ, Dept Environm Hlth Sci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 th Sci, Baltimore, MD 21205 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 10, volume: 97, anno: 2000,
pagine: 5540 - 5545
SICI:
0027-8424(20000509)97:10<5540:NLEIDO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SOMATOSENSORY CORTEX; NMDA GLUTAMATE RECEPTORS; D-ASPARTATE RECEPTORS; MONOCULAR DEPRIVATION; LAYER-IV; RAT; NEOCORTEX; SENSITIVITY; EXPRESSION; ONTOGENY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Wilson, MA Johns Hopkins Univ, Kennedy Krieger Inst, 707 North Broadway, Baltimore, MD 21205 USA Johns Hopkins Univ 707 North Broadway Baltimore MD USA 21205 SA
Citazione:
M.A. Wilson et al., "Neonatal lead exposure impairs development of rodent barrel field cortex", P NAS US, 97(10), 2000, pp. 5540-5545

Abstract

Childhood exposure to low-level lead can permanently reduce intelligence, but the neurobiologic mechanism for this effect is unknown. We examined theimpact of lead exposure on the development of cortical columns, using the rodent barrel field as a model. In all areas of mammalian neocortex, cortical columns constitute a fundamental structural unit subserving information processing. Barrel field cortex contains columnar processing units with distinct clusters of layer IV neurons that receive sensory input from individual whiskers. In this study, rat pups were exposed to 0, 0.2, 1, 1.5, or 2 g/liter lead acetate in their dam's drinking water from birth through postnatal day 10. This treatment, which coincides with the development of segregated columns in the barrel field, produced blood lead concentrations from 1 to 31 mu g/dl. On postnatal day 10, the area of the barrel field and of individual barrels was measured. A dose-related reduction in barrel field areawas observed (Pearson correlation = -0.740; P < 0.001); mean barrel field area in the highest exposure group was decreased 12% Versus controls. individual barrels in the physiologically more active caudoventral group were affected preferentially Total cortical area measured in the same sections wasnot altered significantly by lead exposure. These data support the hypothesis that lead exposure may impair the development of columnar processing units in immature neocortex. We demonstrate that low levers of blood lead, inthe range seen in many impoverished inner-city children, cause structural alterations in a neocortical somatosensory map.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:46:37