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Titolo:
Factors influencing the processing and function of the amyloid beta precursor protein - a potential therapeutic target in Alzheimer's disease?
Autore:
Coughlan, CM; Breen, KC;
Indirizzi:
Univ Dundee, Dept Pharmacol & Neurosci, Dundee Alzheimers Dis Res Ctr, Ninewells Hosp & Med Sch, Dundee DD1 9SY, Scotland Univ Dundee Dundee Scotland DD1 9SY & Med Sch, Dundee DD1 9SY, Scotland Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA UnivPenn Philadelphia PA USA 19104 & Lab Med, Philadelphia, PA 19104 USA
Titolo Testata:
PHARMACOLOGY & THERAPEUTICS
fascicolo: 2, volume: 86, anno: 2000,
pagine: 111 - 144
SICI:
0163-7258(200005)86:2<111:FITPAF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-RELATED PROTEIN; C-TERMINAL FRAGMENT; NERVE GROWTH-FACTOR; NF-KAPPA-B; METABOTROPIC GLUTAMATE RECEPTORS; SULFATE PROTEOGLYCAN FORM; MUSCARINIC ACETYLCHOLINE-RECEPTORS; PHOSPHOTYROSINE-BINDING DOMAIN; PERTURBED CALCIUM HOMEOSTASIS; STIMULATES NEURITE OUTGROWTH;
Keywords:
Alzheimer's disease; amyloid; presenilins; apolipoprotein E; inflammation; calcium;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
496
Recensione:
Indirizzi per estratti:
Indirizzo: Breen, KC Univ Dundee, Dept Pharmacol & Neurosci, Dundee Alzheimers Dis Res Ctr, Ninewells Hosp & Med Sch, Dundee DD1 9SY, Scotland Univ Dundee Dundee Scotland DD1 9SY , Dundee DD1 9SY, Scotland
Citazione:
C.M. Coughlan e K.C. Breen, "Factors influencing the processing and function of the amyloid beta precursor protein - a potential therapeutic target in Alzheimer's disease?", PHARM THERA, 86(2), 2000, pp. 111-144

Abstract

The amyloid beta precursor protein (A beta PP), which plays a pivotal rolein Alzheimer's disease (AD), can exist as either a membrane-bound or soluble protein. The former is cleaved at the level of the plasma membrane to generate the soluble form of the protein (A beta PPs). An alternative pathwayexists, however, for the cleavage of A beta PP to generate a 40-42 amino acid peptide termed amyloid beta (A beta), either within the lysosomal or the endoplasmic reticulum/Golgi compartments of the cell. In AD, there is an increase in the ratio of the 42 amino acid form of the A beta peptide (A beta(42)) to A beta(40). The A beta(42) form is the more amyloidogenic form and has an increased potential to form the insoluble amyloid deposits characteristic of AD pathology. Studies on the familial form of the disease, withmutations in A beta PP or in the presenilin proteins, have confirmed an increase in A beta(42) generation associated with the early stages of the disease. This review will examine the factors that influence A beta PP processing, how they may act to modulate the biological effects of A beta PPs and A beta, and if they provide a viable target for therapeutic intervention tomodify the rate of progression of the disease. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:17:12