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Titolo:
Insulin-dependent diabetes mellitus and oral soft tissue pathologies II. Prevalence and characteristics of Candida and candidal lesions
Autore:
Guggenheimer, J; Moore, PA; Rossie, K; Myers, D; Mongelluzzo, MB; Block, HM; Weyant, R; Orchard, T;
Indirizzi:
Univ Pittsburgh, Sch Dent Med, Dept Restorat Dent, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 at Dent, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Dent Med, Dept Oral Med & Pathol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Pathol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Dent Med, Dept Dent Publ Hlth, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 bl Hlth, Pittsburgh, PA 15261 USA
Titolo Testata:
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS
fascicolo: 5, volume: 89, anno: 2000,
pagine: 570 - 576
SICI:
1079-2104(200005)89:5<570:IDMAOS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BUCCAL EPITHELIAL-CELLS; SECRETOR STATUS; ALBICANS; XEROSTOMIA; INFECTIONS; ADHERENCE; CARRIAGE; COLONIZATION; SMOKING; YEASTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Guggenheimer, J Univ Pittsburgh, Sch Dent Med, Dept Restorat Dent, G-137 Salk,3501 TerraceSt, Pittsburgh, PA 15261 USA Univ Pittsburgh G-137 Salk,3501 Terrace St Pittsburgh PA USA 15261
Citazione:
J. Guggenheimer et al., "Insulin-dependent diabetes mellitus and oral soft tissue pathologies II. Prevalence and characteristics of Candida and candidal lesions", ORAL SURG O, 89(5), 2000, pp. 570-576

Abstract

Objective. To assess the prevalence of Candida albicans and oral infectionwith Candida in patients with insulin-dependent diabetes mellitus (IDDM). Study Design. This cross-sectional study compared the prevalence of candidiasis in 405 subjects with IDDM and 268 nondiabetic control subjects. Assessments included evidence of clinical manifestations of candidiasis and a quantitative measure of Candida pseudohyphae in a cytologic smear from the midline posterior dorsal tongue. Results. More subjects with IDDM than control subjects without IDDM (15.1%vs 3.0%) were found to have clinical manifestations of candidiasis, including median rhomboid glossitis, denture stomatitis, and angular cheilitis. IDDM subjects were also more likely to have any Candida pseudohyphae in their cytologic smears (23.0% vs 5.7%; P < .0001), as well as pseudohyphae counts of >10/cm(2) (7.1% vs 0.8%; P < .0001). Diabetic subjects with median rhomboid glossitis were more likely to have a longer duration of IDDM and complications of nephropathy and retinopathy. Denture stomatitis was associated with smoking, retinopathy, higher Candida counts, poor glycemic control, and longer duration of IDDM. A multivariate regression analysis found 3 factors to be significantly associated with the presence of Candida pseudohyphae in the subjects with IDDM: current use of cigarettes (odds ratio, 2:4), use of dentures (odds ratio, 2:3), and elevated levels of glycosylated hemoglobin (odds ratio, 1:9). The use of antimicrobials, immunosuppressants, ordrugs with xerostomic side effects was not related to the presence of Candida. Conclusions. Candida pseudohyphae and oral soft tissue manifestations of candidiasis were more prevalent in subjects with IDDM than in control subjects without diabetes. The presence of Candida pseudohyphae was significantlyassociated with cigarette smoking, use of dentures, and poor glycemic control.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:21:02