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Titolo:
Radiation therapy for local control of eyelid sebaceous cell carcinoma - Report of two cases and review of the literature
Autore:
Yen, MT; Tse, DT; Wu, XD; Wolfson, AH;
Indirizzi:
Univ Miami, Sch Med, Bascom Palmer Eye Inst, Dept Ophthalmol, Miami, FL 33136 USA Univ Miami Miami FL USA 33136 Inst, Dept Ophthalmol, Miami, FL 33136 USA
Titolo Testata:
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
fascicolo: 3, volume: 16, anno: 2000,
pagine: 211 - 215
SICI:
0740-9303(200005)16:3<211:RTFLCO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLAND CARCINOMA; OCULAR ADNEXA; MANAGEMENT; EXCISION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Tse, DT Univ Miami, Sch Med, Bascom Palmer Eye Inst, Dept Ophthalmol, 900 NW 17th St, Miami, FL 33136 USA Univ Miami 900 NW 17th St Miami FL USA 33136 , Miami, FL 33136 USA
Citazione:
M.T. Yen et al., "Radiation therapy for local control of eyelid sebaceous cell carcinoma - Report of two cases and review of the literature", OPHTHAL PL, 16(3), 2000, pp. 211-215

Abstract

Purpose: Because of previous reports of increased rate of recurrence and mortality after radiation therapy, eyelid sebaceous cell carcinoma has been considered radioresistent. Recent reports of success with primary radiationtherapy have been attributed to advancements in irradiating technology andtechnique. Two cases of eyelid sebaceous cell carcinoma successfully treated with radiation therapy are reported. The techniques used are compared with the techniques described in previous reports, and factors favoring successful treatment are reevaluated. Methods: Case series and review of the literature. Two cases of eyelid sebaceous cell carcinoma that underwent radiation therapy are described. Both patients were offered, but refused, surgical excision. One patient received69 Gy combined superficial and megavoltage x-ray irradiation to the left lower eyelid. The second patient received 59 Gy megavoltage electron beam irradiation to the right upper eyelid. A review of the literature was performed, and Fisher's exact test analysis was used to compare the results of allreported cases treated with less than or equal to 55 Gy with those treatedwith >55 Gy. Results: In both cases, the tumor responded to radiation therapy. One patient died 39 months after treatment, of myocardial infarction. The second patient is without clinical evidence of tumor recurrence 46 months after treatment. Fisher's exact test showed an advantage to patients treated with >55Gy radiation (p = 0.05). Conclusion: Radiation therapy with an appropriate delivery system is effective as a curative treatment for eyelid sebaceous cell carcinoma when >55 Gy of radiation dose is delivered. It should be considered for patients seeking an alternative to surgical excision.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 09:52:40