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Titolo:
Effects of persistent nociception on periaqueductal gray glycine release
Autore:
Maione, S; Marabese, I; Rossi, FS; Berrino, L; Palazzo, E; Trabace, L; Rossi, F;
Indirizzi:
Univ Naples 2, Fac Med & Surg, Inst Pharmacol & Toxicol, I-80138 Naples, Italy Univ Naples 2 Naples Italy I-80138 acol & Toxicol, I-80138 Naples, Italy Univ Bari, Fac Med & Surg, Dept Physiol & Pharmacol, Bari, Italy Univ Bari Bari Italy Med & Surg, Dept Physiol & Pharmacol, Bari, Italy
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 97, anno: 2000,
pagine: 311 - 316
SICI:
0306-4522(2000)97:2<311:EOPNOP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSITU HYBRIDIZATION HISTOCHEMISTRY; SUBUNIT MESSENGER-RNA; FREELY MOVING RATS; SPINAL-CORD; AMINO-ACIDS; BRAIN-STEM; ELECTRICAL-STIMULATION; REGIONAL DISTRIBUTION; MIDBRAIN STIMULATION; DEFENSE REACTION;
Keywords:
glycine; formalin test; PAG area; microdialysis; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Maione, S Univ Naples 2, Fac Med & Surg, Inst Pharmacol & Toxicol, Via Costantinopoli 16, I-80138 Naples, Italy Univ Naples 2 Via Costantinopoli 16 Naples Italy I-80138 Italy
Citazione:
S. Maione et al., "Effects of persistent nociception on periaqueductal gray glycine release", NEUROSCIENC, 97(2), 2000, pp. 311-316

Abstract

Glycine is a candidate nociception inhibitory transmitter in specific brain regions, like for example the spinal cord, the thalamic nuclei and the periaqueductal gray matter. However, quantitative changes in glycine releasedin these brain regions during peripheral inflammation episodes have not been characterized in awake animals. To address this issue, an bt vivo microdialysis study was carried out in freely moving rats in order to analyse periaqueductal gray matter extracellular glycine concentration following unilateral formalin injection into the dorsal skin of the right hind-paw. The extracellular concentration of glutamine was also evaluated in order to analyse whether or not a non-neurotransmitter amino acid was equally modified. Intra-periaqueductal gray matter tetrodotoxin perfusion reduced extracellular glycine concentration (-44 +/- 5%), but did not change the glutamine dialysate values. Peripheral injection of formalin reduced the glycine release during the early phase (-62 +/- 8%) and the late phase (-36 +/- 6%) of hyperalgesia, although not during the analgesic period. Perfusion with naloxone(300 mu M) neither prevented the formalin-induced decreases in extacellular glycine concentration, nor modified the perfusate basal values of glycineand glutamine. These results show that, contrary to what has been recognized on the interactive role of opioids and GABA into the periaqueductal gray matter (i.e. opioid disinhibition), endogenous opioids seem not to modulate the activity of glycinergic neurons in the same midbrain area. In the light of these preliminary data, it is reasonable to suppose that GABA and glycine are probably not co-released at the level of periaqueductal gray matter of the rat. (C) 2000 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:15:36