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Titolo:
Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement
Autore:
Sousa, N; Lukoyanov, NV; Madeira, MD; Almeida, OFX; Paula-Barbosa, MM;
Indirizzi:
Porto Med Sch, Dept Anat, P-4200319 Porto, Portugal Porto Med Sch Porto Portugal P-4200319 t Anat, P-4200319 Porto, Portugal Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 97, anno: 2000,
pagine: 253 - 266
SICI:
0306-4522(2000)97:2<253:ROTMOH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA3 PYRAMIDAL NEURONS; LONG-TERM POTENTIATION; MOSSY FIBER SYNAPSES; RAT DENTATE GYRUS; ADULT-RATS; SPATIAL MEMORY; SYNAPTIC ORGANIZATION; DENDRITIC MORPHOLOGY; COGNITIVE FUNCTION; APICAL DENDRITES;
Keywords:
stress; corticosteroids; synaptic loss; dendritic atrophy; structural reorganization; behavioral correlates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Sousa, N Porto Med Sch, Dept Anat, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal Porto Med Sch Alameda Prof Hernani Monteiro Porto Portugal P-4200319
Citazione:
N. Sousa et al., "Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement", NEUROSCIENC, 97(2), 2000, pp. 253-266

Abstract

We recently demonstrated that stress-induced cognitive deficits in rats donot correlate with hippocampal neuronal loss. Working on the premise that subtle structural changes may however be involved, we here evaluated the effects of chronic stress on hippocampal dendrite morphology, the volume of the mossy fiber system, and number and morphology of synapses between mossy fibers and CA3 dendritic excrescences. To better understand the mechanisms by which stress exerts its structural effects, we also studied these parameters in rats given exogenous corticosterone. Further, to search for signs of structural reorganization following the termination of the stress and corticosterone treatments, we analysed groups of rats returned to treatment-free conditions. All animals were assessed for spatial learning and memory performance in the Morris water maze. Consistent with previous findings, dendritic atrophy was observed in the CA3 hippocampal region of chronically stressed and corticosterone-treated rats; in addition, we observed atrophy in granule and CA1 pyramidal cells following these treatments. Additionally, profound changes in the morphology of the mossy fiber terminals and significant loss of synapses were detected in both conditions. These alterations were partially reversible following rehabilitation from stress or corticosterone treatments. The fine structural changes, which resulted from prolonged hypercortisolism, were accompanied by impairments in spatial learning and memory; the latter were undetectable following rehabilitation. We conclude that there is an intimate relationship between corticosteroid levels, hippocampal neuritic structure and hippocampal-dependent learning and memory. (C) 2000 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:41:10