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Titolo:
Incidence of and risk factors for hallucinations and delusions in patientswith probable AD
Autore:
Paulsen, JS; Salmon, DP; Thal, LJ; Romero, R; Weisstein-Jenkins, C; Galasko, D; Hofstetter, CR; Thomas, R; Grant, I; Jeste, DV;
Indirizzi:
Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 , Dept Psychiat, Iowa City, IA 52242 USA Univ Iowa, Dept Neurol, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 wa, Dept Neurol, Iowa City, IA 52242 USA Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 urosci, La Jolla, CA 92093 USA San Diego Dept Vet Affairs Med Ctr, San Diego, CA USA San Diego Dept Vet Affairs Med Ctr San Diego CA USA r, San Diego, CA USA
Titolo Testata:
NEUROLOGY
fascicolo: 10, volume: 54, anno: 2000,
pagine: 1965 - 1971
SICI:
0028-3878(20000523)54:10<1965:IOARFF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; EXTRAPYRAMIDAL SIGNS; PSYCHIATRIC-SYMPTOMS; LONGITUDINAL COURSE; PSYCHOTIC SYMPTOMS; LEWY BODIES; DEMENTIA; FEATURES; PREDICTORS; VALIDITY;
Keywords:
dementia; delusions; hallucinations; frontal lobes; neuropsychology; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Paulsen, JS Univ Iowa, Dept Psychiat, 200 Hawkins Dr 2880 JPP, Iowa City, IA 52242 USA Univ Iowa 200 Hawkins Dr 2880 JPP Iowa City IA USA 52242 2 USA
Citazione:
J.S. Paulsen et al., "Incidence of and risk factors for hallucinations and delusions in patientswith probable AD", NEUROLOGY, 54(10), 2000, pp. 1965-1971

Abstract

Objective: To examine the incidence of and risk facto rs for hallucinations and delusions associated with patients clinically diagnosed with probableAD. Background: Estimates of the incidence of psychosis in AD range widelyfrom 10% to 75%. The risk factors for psychosis of AD are not known, although multiple studies indicate that AD patients with psychosis demonstrate greater cognitive and functional impairment. Methods: The authors conducted psychiatric evaluations of 329 patients with probable AD from the University of California at San Diego Alzheimer's Disease Research Center to determine the incidence of hallucinations and delusions. The examined data from annual clinical and neuropsychological evaluations to determine whether therewere specific risk factors for the development of hallucinations and delusions. Results: Using Cox survival analyses, the cumulative incidence of hallucinations and delusions was 20.1% at 1 year, 36.1% at 2, 49.5% at 3, and 51.3% at 4 years. Parkinsonian gait, bradyphrenia, exaggerated general cognitive decline, and exaggerated semantic memory decline were significant :predictors. Age, education, and gender were not significant predictors. Conclusions: The authors found a relatively high incidence of hallucinations anddelusions in patients diagnosed with probable AD and suggest that specificneurologic signs, cognitive abilities, and accelerated decline may be predictive markers for their occurrence.

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Documento generato il 02/04/20 alle ore 12:59:53