Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Estrogen use, APOE, and cognitive decline - Evidence of gene-environment interaction
Autore:
Yaffe, K; Haan, M; Byers, A; Tangen, C; Kuller, L;
Indirizzi:
Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Ctr Aging, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA San Francisco Vet Adm, San Francisco, CA USA San Francisco Vet Adm San Francisco CA USA et Adm, San Francisco, CA USA Univ Calif Davis, Dept Epidemiol & Prevent Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 ol & Prevent Med, Davis, CA 95616 USA Yale Univ, Dept Epidemiol & Publ Hlth, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 iol & Publ Hlth, New Haven, CT 06520 USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 idemiol, Pittsburgh, PA 15260 USA
Titolo Testata:
NEUROLOGY
fascicolo: 10, volume: 54, anno: 2000,
pagine: 1949 - 1953
SICI:
0028-3878(20000523)54:10<1949:EUAACD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E POLYMORPHISM; ALZHEIMERS-DISEASE; REPLACEMENT THERAPY; OLDER WOMEN; CAROTID ATHEROSCLEROSIS; CARDIOVASCULAR HEALTH; POSTMENOPAUSAL WOMEN; RISK; MENOPAUSE; DEMENTIA;
Keywords:
estrogen; APOE; cognitive decline; elderly women;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Yaffe, K Box 111G, San Francisco, CA 94121 USA Box 111G San Francisco CA USA 94121 San Francisco, CA 94121 USA
Citazione:
K. Yaffe et al., "Estrogen use, APOE, and cognitive decline - Evidence of gene-environment interaction", NEUROLOGY, 54(10), 2000, pp. 1949-1953

Abstract

Objective: APOE-epsilon 4 increases the risk of cognitive decline, while elderly women who take estrogen may have less risk of cognitive decline. Theauthors sought to determine whether estrogen use modifies the association between APOE-epsilon 4 and cognitive decline. Method: As part of the Cardiovascular Health Study, 3,393 Medicare-eligible women (greater than or equalto 65 years) were randomly selected and recruited from Sacramento County, CA; Washington County, MD; Forsyth County, NC; and Pittsburgh, PA. Cognitive testing was administered annually; the authors studied the 2,716 women with cognitive testing on greater than or equal to 2 visits. They analyzed change in score on the Modified Mim-Mental State Examination (3MS) as a function of estrogen use, APOE genotype, and baseline common and internal carol;id artery wall thickening. Results: A total of 297 (11%) women were currentestrogen users and 336 (12%) were past estrogen users. Over the 6-year average follow-up, baseline current users declined 1.5 points on the 3MS whereas never users declined 2.7 points (p = 0.023). Compared with epsilon 4-negative women, epsilon 4-positive women had a greater adjusted hazard ratio of cognitive impairment (3MS < 80), hazard risk [HR] = 1.47; 95% CI, 1.13 to1.90. There was an interaction between estrogen use and epsilon 4 presence(p = 0.037). Among epsilon 4-negative women, current estrogen use reduced the risk of adjusted cognitive impairment compared with never users by almost half(HR = 0.59; 95% CI, 0.36 to 0.99), whereas, it did not reduce the risk among epsilon 4-positive women (current use, HR = 1.33; 95% CI, 0.74 to 2.42). Compared with never use, current estrogen use was associated with less internal and common carotid wall thickening in epsilon 4-negative women but not in epsilon 4-positive women (p for interaction < 0.05 for both). Differences remained after adjusting for age, education, race, and stroke. Conclusions: Estrogen use was associated with less cognitive decline among epsilon 4-negative women but not epsilon 4-positive women. Potential mechanisms, including carotid atherosclerosis, by which epsilon 4 may interact withestrogen and cognition warrant further investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:50:11