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Titolo:
The long-duration response to L-dopa in the treatment of early PD
Autore:
Zappia, M; Oliveri, RL; Bosco, D; Nicoletti, G; Branca, D; Caracciolo, M; Napoli, ID; Gambardella, A; Quattrone, A;
Indirizzi:
Fac Med, Neurol Clin, I-88100 Catanzaro, Italy Fac Med Catanzaro Italy I-88100 d, Neurol Clin, I-88100 Catanzaro, Italy Univ Catanzaro, Inst Neurol, Cantanzaro, Italy Univ Catanzaro CantanzaroItaly tanzaro, Inst Neurol, Cantanzaro, Italy
Titolo Testata:
NEUROLOGY
fascicolo: 10, volume: 54, anno: 2000,
pagine: 1910 - 1915
SICI:
0028-3878(20000523)54:10<1910:TLRTLI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; MOVEMENT TIME; LEVODOPA TEST; PHARMACODYNAMICS; THERAPY;
Keywords:
PD; L-dopa; long-duration response; pharmacodynamics; movement time;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Quattrone, A Fac Med, Neurol Clin, Via T Campanella, I-88100 Catanzaro, Italy Fac Med Via T Campanella Catanzaro Italy I-88100 zaro, Italy
Citazione:
M. Zappia et al., "The long-duration response to L-dopa in the treatment of early PD", NEUROLOGY, 54(10), 2000, pp. 1910-1915

Abstract

Objective: To investigate the long-duration response (LDR) to L-dopa resulting from different regimens of L-dopa. Background: In clinical practice, L-dopa is usually administered without considering the LDR due to the drug. Moreover, it has not been established whether in early PD a multiple daily intake of small doses of L-dopa may induce a sustained LDR. Methods: Twenty-four patients with early PD underwent a double-blind, crossover trial, comparing three different 15-day treatment periods with L-dopa: treatment A (250 mg every 24 hours); treatment B (250 mg every 8 hours); and treatment C (125 mg every 8 hours). After completion, 20 patients underwent a subsequent open-label randomized trial with prolonged treatments (250 mg every 24 hours or 125 mg every 8 hours) up to 3 months. LDR was measured at the end ofeach treatment. Results. All patients achieved a sustained LDR after treatments A and B, whereas only 17% of patients reached a sustained LDR after treatment C. Overall, the LDRs resulting from treatments A and B had similarmagnitude and were larger than the LDR deriving from treatment C. After 3 months of prolonged treatments, only three of 10 patients treated with 125 mg every 8 hours increased their LDR, whereas all 10 patients treated with 250 mg every 24 hours had a maximal and stable LDR. Conclusions: Sustained LDR to L-dopa is dependent on the amount of the single doses of the drug. Aregimen scheduling small, divided doses during the day, as done in clinical practice, is a questionable therapy for the achievement of a sustained LDR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:44:52