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Titolo:
The effect of cholinergic, GABAergic, serotonergic, and glutamatergic receptor modulation on posttrial memory processing in the hippocampus
Autore:
Farr, SA; Flood, JF; Morley, JE;
Indirizzi:
VA Med Ctr, Ctr Geriatr Res Educ & Clin, St Louis, MO 63109 USA VA Med Ctr St Louis MO USA 63109 Res Educ & Clin, St Louis, MO 63109 USA St Louis Univ, Sch Med, Dept Internal Med, Div Geriatr Med, St Louis, MO 63106 USA St Louis Univ St Louis MO USA 63106 v Geriatr Med, St Louis, MO 63106 USA
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 2, volume: 73, anno: 2000,
pagine: 150 - 167
SICI:
1074-7427(200003)73:2<150:TEOCGS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGE-RELATED-CHANGES; RAT HIPPOCAMPUS; ACETYLTRANSFERASE IMMUNOCYTOCHEMISTRY; INHIBITORY INTERNEURONS; DRUG FACILITATION; DIFFERENT PARTS; MEDIAL SEPTUM; ANTAGONISTS; NEURONS; MICE;
Keywords:
acetylcholine; aversive conditioning; GABA; glutamate; hippocampus; memory; mice; retention; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Farr, SA VA Med Ctr, Ctr Geriatr Res Educ & Clin, 915 N Grand Blvd, St Louis, MO 63109 USA VA Med Ctr 915 N Grand Blvd St Louis MO USA 63109 s, MO 63109 USA
Citazione:
S.A. Farr et al., "The effect of cholinergic, GABAergic, serotonergic, and glutamatergic receptor modulation on posttrial memory processing in the hippocampus", NEUROBIOL L, 73(2), 2000, pp. 150-167

Abstract

Though the hippocampus is widely recognized as important in learning and memory, most of the evidence for this comes from animal lesion and human pathological studies. Due to the relatively small number of drugs that have been tested in the hippocampus for their ability to alter posttrial memory processing, there is a general impression that memory processing involves only a few neurotransmitters. We have evaluated the effects of cholinergic, GABAergic, serotonergic, and glutamatergic receptor agonists and antagonists for their ability to facilitate or impair retention. CD-I mice received acute intrahippocampal drug infusion following footshock avoidance training ina T-maze. Retention was tested 1 week after training and drug administration. The results indicate that receptor agonists of acetylcholine and glutamate improved retention, while antagonists impaired retention. However, scopolamine did not impair retention, but M1 and M2 antagonists did. Receptor agonists of serotonin and GABA impaired retention, while antagonists improved retention. Drugs acting on 5-HT-1 and 5-HT-2 as well as GABAA and GABAB receptor subtypes did not differentially effect retention, (C) 2000 AcademicPress.

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Documento generato il 07/04/20 alle ore 22:39:23