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Titolo:
Role of supraspinal tachykinins for micturition in conscious rats with andwithout bladder outlet obstruction
Autore:
Gu, BJ; Ishizuka, O; Igawa, Y; Nishizawa, O; Andersson, KE;
Indirizzi:
Shinshu Univ, Sch Med, Dept Urol, Matsumoto, Nagano 3908621, Japan ShinshuUniv Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan Univ Lund Hosp, Dept Clin Pharmacol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 Clin Pharmacol, S-22185 Lund, Sweden
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 5, volume: 361, anno: 2000,
pagine: 543 - 548
SICI:
0028-1298(200005)361:5<543:ROSTFM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFRAVESICAL OUTFLOW OBSTRUCTION; SUBSTANCE-P; URINARY-BLADDER; SPINAL-CORD; NK2 RECEPTOR; CAPSAICIN; REFLEX; ANTAGONIST; HYPERACTIVITY; INSTABILITY;
Keywords:
NK-receptors; bladder hyperactivity; micturition reflex; urinary incontinence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Ishizuka, O Shinshu Univ, Sch Med, Dept Urol, Asahi 3-1-1, Matsumoto, Nagano 3908621, Japan Shinshu Univ Asahi 3-1-1 Matsumoto Nagano Japan 3908621 Japan
Citazione:
B.J. Gu et al., "Role of supraspinal tachykinins for micturition in conscious rats with andwithout bladder outlet obstruction", N-S ARCH PH, 361(5), 2000, pp. 543-548

Abstract

In order to clarify the role of supraspinal tachykinins in volume-induced micturition and in bladder hyperactivity secondary to bladder outlet obstruction, conscious, normal, female Sprague-Dawley rats were investigated cystometrically before and after intracerebroventricular administration of RP 67,580, a selective antagonist of neurokinin (NK)-1 receptors and/or SR 48,968, a selective antagonist of NK-2 receptors. In normal rats, RP 67,580 or SR 48,968, at a dose of 2 nmol, caused no marked changes in cystometric parameters. Higher doses (up to 20 nmol) caused dose-dependent decreases in micturition pressure and increased bladder capacity, micturition volume and residual urine. A combination of the two drugs, each at a dose of 2 nmol, significantly decreased micturition pressure and increased bladder capacity. In rats with bladder outlet obstruction: the antagonists suppressed micturition dose-dependently, producing urinary retention in two out of eight rats already at a dose of 2 nmol. At a dose of 20nmol, dribbling incontinence, due to urinary retention, was seen in five out of ten rats. A combination of the two drugs (2 nmol of each drug) causedurinary retention in three out of nine animals and significantly increasedbladder capacity, micturition volume and residual volume. The results suggest that outflow obstruction in rats increases the effectsof tachykinins in supraspinal structures involved in micturition, and thatantagonism of supraspinal NK-receptors may depress the micturition reflex. Whether or not this implies that supraspinal NK-receptors can be targets for drugs aimed for inhibiting bladder hyperactivity in humans should be explored.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 04:05:06