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Titolo:
Apoptosis: Future directions in cancer therapy
Autore:
Ravi, D; Panikkar, KR; Nair, MK; Pillai, MR;
Indirizzi:
Reg Canc Ctr, Div Lab Med, Thiruvananthapuram 695011, Kerala, India Reg Canc Ctr Thiruvananthapuram Kerala India 695011 695011, Kerala, India Reg Canc Ctr, Div Radiat Oncol, Thiruvananthapuram 695011, Kerala, India Reg Canc Ctr Thiruvananthapuram Kerala India 695011 695011, Kerala, India
Titolo Testata:
NATIONAL MEDICAL JOURNAL OF INDIA
fascicolo: 2, volume: 13, anno: 2000,
pagine: 71 - 78
SICI:
0970-258X(200003/04)13:2<71:AFDICT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; POLY(ADP-RIBOSE) POLYMERASE; CYTOCHROME-C; TUMOR-CELLS; INTRACELLULAR ACIDIFICATION; MITOCHONDRIAL CONTROL; PROTEASE ACTIVATION; NUCLEAR APOPTOSIS; RECEPTOR GENE; CYCLE ENTRY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Pillai, MR Reg Canc Ctr, Div Lab Med, Thiruvananthapuram 695011, Kerala, India Reg Canc Ctr Thiruvananthapuram Kerala India 695011 ala, India
Citazione:
D. Ravi et al., "Apoptosis: Future directions in cancer therapy", NAT MED J I, 13(2), 2000, pp. 71-78

Abstract

Cancer as a multifactorial disease results in gain of immortality due to defective apoptosis, The primary mode of cell death by apoptosis induced by various modes of treatment often failin vivo. The in vitro environment is less complex while the in vivo environment is influenced by various externalregulatory signals besides the existence of multiple, parallel and independent apoptotic pathways. Further, specific preference for an apoptotic pathway in a certain cell type would significantly alter the apoptotic responses. Identification of defects in preferred pathways and choosing alternativeand potentially inducible pathways would help in deciding on apoptosis-based treatment protocols. Mechanisms involved in the execution of apoptosis may also not be unique to apoptotic pathways since similar events, possibly with strict control, do occur during mitosis. Further evaluation may yield new dimensions to apoptosis and apoptosis-based therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 01:56:42