Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Atherosclerosis risk factors: the possible role of homocysteine
Autore:
Choy, PC; Mymin, D; Zhu, QS; Dakshinamurti, K; O, K;
Indirizzi:
Univ Manitoba, Fac Med, Dept Biochem & Mol Biol, Lipid Res Grp, Winnipeg, MB R3E 0W3, Canada Univ Manitoba Winnipeg MB Canada R3E 0W3 rp, Winnipeg, MB R3E 0W3, Canada Univ Hong Kong, Fac Med, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
MOLECULAR AND CELLULAR BIOCHEMISTRY
fascicolo: 1-2, volume: 207, anno: 2000,
pagine: 143 - 148
SICI:
0300-8177(200004)207:1-2<143:ARFTPR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATION; APOLIPOPROTEIN-B SECRETION; LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE CELLS; PLASMA HOMOCYSTEINE; VASCULAR-DISEASE; FAMILIAL HYPERCHOLESTEROLEMIA; CARDIOVASCULAR-DISEASE; NITRIC-OXIDE; CHOLESTEROL;
Keywords:
atherosclerosis; lipoprotein; cholesterol; homocysteine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Choy, PC Univ Manitoba, Fac Med, Dept Biochem & Mol Biol, Lipid Res Grp, 770 Bannatyne Ave, Winnipeg, MB R3E 0W3, Canada Univ Manitoba 770 Bannatyne Ave Winnipeg MB Canada R3E 0W3 Canada
Citazione:
P.C. Choy et al., "Atherosclerosis risk factors: the possible role of homocysteine", MOL C BIOCH, 207(1-2), 2000, pp. 143-148

Abstract

Atherosclerosis is the leading cause of death in North America. It is characterized by thickening of the coronary artery wall by the formation of plaques, resulting in reduced blood flow. Plaque rupture and the consequent thrombosis may lead to sudden blockage of arteries and causing stroke and heart attack. In the last several decades, more than 250 factors associated with the development of coronary artery disease have been identified. Recently, a relationship between atherosclerosis and elevated homocysteine level in the blood has been established. The mechanism for the production of atherosclerosis by homocysteine has been investigated. When human hepatoma cells(HepG2) were incubated with 4mM homocysteine, enhancements in the production of cholesterol and secretion of apolipoprotein B-100 were observed. The stimulatory effect on cholesterol synthesis was mediated via the enhancement of HMG-CoA reductase, which catalyzes the rate-limiting step in cholesterol biosynthesis. Cholesterol appears to play an important role in the regulation of apoB-100 secretion by hepatocytes. It is plausible that the increase in apoB secretion was caused by the elevated cholesterol level induced by homocysteine. The ability of homocysteine to produce a higher amount of cholesterol and promote the secretion of apoB would provide a plausible mechanism for the observed relationship between hyperhomocysteinemia and the development of atherogenesis and coronary artery disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:48:54