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Titolo:
Protective immune responses induced by a non-pathogenic simian/human immunodeficiency virus (SHIV) against a challenge of a pathogenic SHIV in monkeys
Autore:
Yoshino, N; Ami, Y; Someya, K; Ando, S; Shinohara, K; Tashiro, F; Lu, YC; Honda, M;
Indirizzi:
Natl Inst Infect Dis, AIDS Res Ctr, Vaccine Res & Dev Grp, Shinjuku Ku, Tokyo 1628640, Japan Natl Inst Infect Dis Tokyo Japan 1628640 injuku Ku, Tokyo 1628640, Japan Natl Inst Infect Dis, Div Expt Anim Res, Shinjuku Ku, Tokyo 1628640, JapanNatl Inst Infect Dis Tokyo Japan 1628640 injuku Ku, Tokyo 1628640, Japan Natl Inst Infect Dis, Div Biosafety Control & Res, Shinjuku Ku, Tokyo 1628640, Japan Natl Inst Infect Dis Tokyo Japan 1628640 injuku Ku, Tokyo 1628640, Japan Sci Univ Tokyo, Fac Ind Sci & Technol, Noda, Chiba 2780022, Japan Sci UnivTokyo Noda Chiba Japan 2780022 chnol, Noda, Chiba 2780022, Japan Inst Int Vaccine Dev Inc, Cambridge, MA USA Inst Int Vaccine Dev Inc Cambridge MA USA ine Dev Inc, Cambridge, MA USA Virus Res Inst Inc, Cambridge, MA USA Virus Res Inst Inc Cambridge MA USA irus Res Inst Inc, Cambridge, MA USA
Titolo Testata:
MICROBIOLOGY AND IMMUNOLOGY
fascicolo: 5, volume: 44, anno: 2000,
pagine: 363 - 372
SICI:
0385-5600(2000)44:5<363:PIRIBA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; T-CELLS; HIV-1 INFECTION; RHESUS MACAQUES; DOWN-REGULATION; ATTENUATED SIV; CHIMERIC VIRUS; FAS ANTIGEN; IN-VIVO; LIVE;
Keywords:
infectious immunity; pathogenic virus; protection; helper T-cell function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Honda, M Natl Inst Infect Dis, AIDS Res Ctr, Vaccine Res & Dev Grp, Shinjuku Ku, Tokyo 1628640, Japan Natl Inst Infect Dis Tokyo Japan 1628640 , Tokyo 1628640, Japan
Citazione:
N. Yoshino et al., "Protective immune responses induced by a non-pathogenic simian/human immunodeficiency virus (SHIV) against a challenge of a pathogenic SHIV in monkeys", MICROB IMMU, 44(5), 2000, pp. 363-372

Abstract

A simian/human immunodeficiency virus (SHIV)-NM3n containing the human nef, but not the monkey nef, and vpr genes of SIV was inoculated into two cynomolgus monkeys, resulting in systemic infection with a minimum level of transient virus load. In order to study the nature of immune responses associated with the prevention of a pathogenic SHIV, the SHIV-NM3n-inoculated monkeys and three naive monkeys were intravenously challenged with a pathogenicSHIV containing the envelope gene of HIV-1 89.6. After the heterologous virus challenge, all of the SHIV-NM3n-inoculated animals completely avoided the loss of CD4(+) T lymphocytes in PBMC as well as lymphoid tissues compared to pathogenic SHIV-injected control animals. The inhibition of CD4(+) cell depletion was associated with maintaining the proliferative response of helper T-cells against SIV p27 in the previously nonpathogenic virus-inoculated animals following the pathogenic virus challenge. Furthermore, the decline of CD28(+) cells, the increase in CD95(+) cells, and the enhancement ofin vitro apoptosis in PBMC were inhibited in the non-pathogenic virus-inoculated animals. These results suggest that nonpathogenic SHIV-NM3n infection induces the protection of monkeys from heterologous pathogenic viruses that may be associated with blocking the change in immune responses and the cell loss induced by a pathogenic virus.

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Documento generato il 04/04/20 alle ore 07:13:00